Granulocyte-macrophage colony-stimulating factor receptor and de

Details Granulocyte-macrophage colony-stimulating factor receptor and de Granulocyte-macrophage colony-stimulating factor receptor and de

1994-11-23

1997-05-13

Ulm, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530350, 530351, 530395, 536 235, 435 691, C07K 14705, C12N 1512

Patent

active

056292830

ABSTRACT:
The invention provides a recombinant or synthetic receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) and biochemical and/or biological equivalents, homologues, or derivatives thereof. The GM-CSF receptor is useful inter alia in treatment and diagnosis of GM-CSF related diseases, and in screening of agonists and antagonists of binding of GM-CSF to its cell-bound receptors. The invention further provides nucleic acid sequences encoding GM-CSF receptor, recombinant DNA molecules comprising these sequences, and transformed hosts carrying the recombinant DNA molecules, as well as antibodies directed against GM-CSF receptor, and pharmaceutical compositions comprising either the GM-CSF receptor or antibodies thereto.

REFERENCES:
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Lewin, Scume 237, 1987, pg.
Raines et al, PNAS 88, 1991, pp. 8203-8207.
Di Persi et al, JBC, 1991, pp. 279-286, vol. 266.
Baldwin et al, Blood 78, 1991, pp. 609-615.
Metcalf et al, PNAS 87, 1990, pp. 4670-4674.
DiPersio et al., Human granulocyte-macrophage colony-stimulating factor and other cytokines prime human neutrophiles for enhanced arachidonic acid release and leukotriene B.sub.4 synthesis, The Journal of Immunology, 140:4315-4322 (1988).
Gearing, D.P., The EMBO Journal 8(12):3667-3676 (1989).
Gough, N.M., Nature 345:734-736 (1990).
Reeck et al Cell 50 667 (1987).

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