Granulocyte-macrophage colony-stimulating factor receptor and de

Details Granulocyte-macrophage colony-stimulating factor receptor and de Granulocyte-macrophage colony-stimulating factor receptor and de

1995-02-07

1998-03-10

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 536 235, 536 243, C12N 1512, C07K 14715

Patent

active

057260362

ABSTRACT:
The invention provides a recombinant or synthetic receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) and biochemical and/or biological equivalents, homologues, or derivatives thereof. The GM-CSF receptor is useful inter alia in treatment and diagnosis of GM-CSF related diseases, and in screening of agonists and antagonists of binding of GM-CSF to its cell-bound receptors. The invention further provides nucleic acid sequences encoding GM-CSF receptor, recombinant DNA molecules comprising these sequences, and transformed hosts carrying the recombinant DNA molecules, as well as antibodies directed against GM-CSF receptor, and pharmaceutical compositions comprising either the GM-CSF receptor or antibody thereto.

REFERENCES:
patent: 5112961 (1992-05-01), Hayashida et al.
Baldwin, G.C., et al., "Identification and Characterization of a Low-Affinity Granulocyte-Macrophage Colony-Stimulating Factor Receptor on Primary and Cultured Human Melanoma Cells," Blood 78(3):609-615 (Aug. 1, 1991).
DiPersio, J.F., et al., "Human Granulocyte-Macrophage Colony-Stimulating Factor and Other Cytokines Prime Human Neutrophils for Enhanced Arachidonic Acid Release and Leukotriene B.sub.4 Synthesis," J. Immunol. 140:4315-4322 (Jun. 15, 1988).
DiPersio, J.F., et la., "Characterization of the Soluble Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor Complex," J. Biol. Chem. 266(1):279-286 (Jan. 5, 1991).
Gearing, D.P., et al., "Expression Cloning of a Receptor for Human Granulocyte-Macrophage Colony-Stimulating Factor," EMBO J. 8(12):3667-3676 (Dec. 1, 1989).
Gough, N.M., et al., "Localization of the Human GM-CSF Receptor Gene to the X-Y Pseudoutosomal Region," Nature 345:734-736 (Jun. 21, 1990).
Lewin, R., "When Does Homology Mean Something Else?," Science 237:1570 (Sep. 25, 1987).
Metcalf, D., et al., "Low-Affinity Placenta-Derived Receptors for Human Granulocyte-Macrophage Colony-Stimulating Factor Can Deliver a Proliferative Signal to Murine Hemopoietic Cells," Proc. Natl. Acad. Sci. USA 87:4670-4674 (Jun. 1990).
Raines, J.A., et al., "Identification and Molecular Cloning of a Soluble Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor." Proc. Natl. Acad. Sci. USA 88:8203-8207 (Sep. 1991).
Reeck, G.R., et al., "`Homology` in Proteins and Nucleic Acids: A Terminology Muddle and a Way Out Of It," Cell 50:667 (Aug. 28, 1987).
DiPersio, J. et al., "Characterization of the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor," J. Biol. Chem. 263(4):1834-1841 (Feb. 5, 1988).

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