Granulated preparations and method of producing the same

Details Granulated preparations and method of producing the same Granulated preparations and method of producing the same

1994-03-25

1995-08-22

Bleutge, John C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424502, A61K 916

Patent

active

054438462

ABSTRACT:
Granulated preparations are provided by causing a granular, preferably spherical polyglycerol fatty acid ester having a melting poing of 40.degree.-80.degree. C. together with a powder for fluidized bed formation and heating the resulting fluidized mixture at a temperature in the vicinity of the melting point of the polyglycerol fatty acid ester. The powder may be contain as least one pharmacologically active ingredient. The polyglycerol fatty acid ester shows no crystal polymorphism and does not inactivate the pharmacologically active ingredient. Furthermore, the dissolution and release of the pharmacologically active ingredient can be controlled by varying the HLB of the polyglycerol fatty acid ester.

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Taiko Pharmaceutical, Chemical Abstracts, vol. 101 No. 16 p. 391 (1984) Abstract No. 137025k.

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