Granulate or powder for producing coating or binding agents...

Details Granulate or powder for producing coating or binding agents... Granulate or powder for producing coating or binding agents...

2007-02-13

2007-02-13

Tran, S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S490000

Reexamination Certificate

active

10489856

ABSTRACT:
The invention relates to a process for the production of granules or powders, suitable as coating agents and binders for oral or dermal pharmaceutical forms, for cosmetics or food supplements, consisting essentially of (a) a copolymer, consisting of free radical-polymerized C1- to C4-esters of acrylic or methacrylic acid and further (meth)acrylate monomers which contain functional tertiary amino groups, (b) 3 to 25% by weight, based on (a), of an emulsifier having an HLB of at least 14, (c) 5 to 50% by weight, based on (a), of a C12- to C18-monocarboxylic acid or of a C12- to C18-hydroxyl compound, where the components (a), (b) and (c) are simultaneously or successively blended or mixed with one another, optionally with addition of a pharmaceutical active compound and/or further customary additives, fused in a heatable mixer, mixed, the melt is cooled and comminuted to give granules or powders.

REFERENCES:
patent: 6576255 (2003-06-01), Petereit et al.
patent: 6624210 (2003-09-01), Petereit et al.
patent: 2003/0064036 (2003-04-01), Petereit et al.
patent: 2004/0253314 (2004-12-01), Petereit et al.
patent: 0164669 (1985-12-01), None
patent: 0403959 (1990-12-01), None
patent: 0727205 (1996-08-01), None
patent: WO 0005307 (2000-02-01), None
E. Roth, et al. “Improved moisture protection with new aqueous aminomethacrylate copolymer formulations”, CRS, Annual meeting 2002 in Seoul (Korea) 2002.
Hans-Ulrich Petereit, “New aspects of moisture protection and insulation of solid dosage forms with EUDRAGIT® EPO”, 33st International EUDRAGIT® Workshop 2001, Sep. 27-28, 2001.

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