Granular product or tablet containing an effervescent system and

Details Granular product or tablet containing an effervescent system and Granular product or tablet containing an effervescent system and

1996-03-22

1998-08-11

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424489, 424490, A61K 946, A61K 916

Patent

active

057924732

ABSTRACT:
In accordance with this invention there is provided a granular product with an effervescent system which comprises acid-sensitive pharmaceutically active substances, such as, for example, betacarotene, cimetidine, ranitidine or cisapride, which is specially useful to prevent antacid action, having an acid-neutralizing capacity below about 5 meq, at a weight of about 1.6 to about 2.3 grams. The effervescent grains are made from carrier crystals of at least one solid, edible organic acid, preferably citric acid and/or tartaric acid, and are present as a granular product, separate from the pharmaceutically active substance, and are coated with at least one layer of a neutral substance which is soluble in water and/or alcohol and which is able to bring about a melting point depression of the acid grains at their surface, such as, for example, a water-soluble polymer, a polyalcohol, a carbohydrate and/or a hydrocolloid. A second coating contains at least a part of the alkali and/or alkaline earth carbonate or bicarbonate provided for the total dosage.

REFERENCES:
patent: 4127645 (1978-11-01), Witzel et al.
patent: 4704269 (1987-11-01), Korab
patent: 4824664 (1989-04-01), Tarral et al.
patent: 4867942 (1989-09-01), Gergely et al.
patent: 5102665 (1992-04-01), Schaeffer
patent: 5503846 (1996-04-01), Wehling et al.

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