Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1993-10-19
1996-02-06
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424458, 424490, A61K 914
Patent
active
054894395
ABSTRACT:
A process for the preparation of a granule comprising a pharmaceutical which process comprises contacting a particulate, spray-dried substrate and a particulate pharmaceutical to obtain a particle comprising a substrate core carrying an adsorbed pharmaceutical and contacting the particle with a particulate pharmaceutical and a melted or thermally softened pharmaceutically acceptable excipient which is solid at room temperature to obtain, after cooling to solidify or harden the excipient, a granule comprising a spray-dried substrate core carrying pharmaceutically acceptable excipient and pharmaceutical.
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Journal of Pharmacy and Pharmacology, vol. 36, Sep. 1984, London W. J. Thiel et al. "Fluidized bed film coating of an ordered powder mixture to produce microencapsulated ordered units" pp. 145-152.
Die Pharmazie, 34, vol. 12, Dec. 1979, Berlin H. Kala et al. "Anwedung der spruhtrocknug in der Pharmazie" pp. 779-784.
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European Search Report, dated Dec. 22, 1989.
Benston, Jr. William E.
May & Baker Ltd.
Page Thurman K.
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