Granular delayed-release form of pharmaceutically active substan

Details Granular delayed-release form of pharmaceutically active substan Granular delayed-release form of pharmaceutically active substan

1986-07-23

1988-03-01

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424468, 424480, 424495, 424153, 424151, 514 81, 514 89, 514 62, 514100, A61K 3314, A61K 3178

Patent

active

047285133

ABSTRACT:
A granular delayed-release form of pharmaceutically active substances, which is prepared by coating a granulated or crystalline pharmaceutically active substance, or mixtures thereof, with a coating material mixture consisting essentially of a homogeneous mixture of a poly(H+meth)-acrylic acid-(methyl+ethyl)ester which is insoluble but dispersible in water and an ethyl cellulose which is insoluble but dispersible in water in the weight ratio of 20:1 to 1:5, is presented, which is characterized by the fact that the coated granules are heated for at least 5 minutes at elevated temperatures ranging from between 50.degree. to 120.degree. C.

REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3712867 (1973-01-01), Schon et al.
patent: 4083949 (1978-04-01), Benedikt
patent: 4150110 (1979-04-01), Yoshida et al.

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