Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Specially adapted for ruminant animal
Patent
1989-01-05
1990-08-14
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Specially adapted for ruminant animal
424442, 424490, 424498, A23K 118, A61K 916
Patent
active
049485890
ABSTRACT:
A granular composition for a ruminant containing as a main component choline or a physiologically acceptable derivative thereof, wherein the composition is prepared by (1) granulating the choline or it derivative having an average particle size of 100 .mu.m or less and a maximum particle size of 150 .mu.m or less, an excipient having an average particle size of 10 .mu.m or less and a maximum particle size of 20 .mu.m or less, and a hydrophobic binder under a relative humidity of 10% or less by using an agitation granulator, followed by cooling, separating and classifying the resultant granules to obtain spherical granules having a particle size of 0.5 to 2.5 mm and (ii) forming a thin film on the surface of the granules at a temperature of at least 5.degree. C. less than a melting point of the binder and 5.degree. C. to 25.degree. C. less than a melting point of the overcoating agent under a relative humidity of 30% or less in an agitation granulator by adding 20 to 40 parts by weight, based on 100 parts by weight of the granules, of a heated molten mixture of a hydrophobic overcoating agent and a solubility modifier in the form of a fine powder in a weight ratio of 1:0.2-1.
REFERENCES:
patent: T100404 (1981-03-01), Wu
patent: 3492398 (1970-01-01), Marco et al.
patent: 3697640 (1972-10-01), Grant et al.
patent: 4675175 (1987-06-01), Autant et al.
patent: 4713245 (1987-12-01), Ando et al.
patent: 4842863 (1989-06-01), Nishimura et al.
Iijima Hitoshi
Kiuchi Masayuki
Nakao Masahiro
Nishimura Kunio
Sato Shigeaki
Page Thurman K.
Showa Denko Kabushiki Kaisha
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