Granular anhydrous dicalcium phosphate compositions suitable for

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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423307, 423308, 424 57, 424128, 424474, 514835, C01B 1516, C01B 2526, A61K 3306, A61K 716

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047073616

ABSTRACT:
A granular anhydrous dicalcium phosphate having a particle of a size sufficient for direct compression tablets and a surface area of greater than 5 meters.sup.2 /gram can be direct compression tableted. This product can be prepared by dehydrating granules of dicalcium phosphate dihydrate of a particle size sufficient for direct compression tableting and sufficiently large to allow the dehydration of the granules without lumping and without fracturing a majority of the granules. The granules are heated at a temperature sufficient to form anhydrous dicalcium phosphate. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility, flowability and whiteness while being in an anhydrous state.

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