Granular anhydrous dicalcium phosphate compositions suitable for

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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424 57, 424128, 424465, 423307, 423308, 514835, 514778, 514780, C01B 1516, C01B 2526, A61K 3306, A61K 716

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046751882

ABSTRACT:
A granular directly compressible anhydrous dicalcium phosphate having a particle size sufficient for efficient direct compression tableting, preferably at least 90 percent greater than 44 microns, a dentin abrasion value of less than 150 and a surface area of greater than 5 meters.sup.2 /gram can be prepared by dehydrating particles of soft dicalcium phosphate dihydrate of a particle size insufficient for direct compression tableting, preferably at least 10 percent less than about 44 microns such as by heating at a temperature sufficient to form anhydrous dicalcium phosphate. The dehydrated particles are then granulated with a binder. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility and flowability while being in an anhydrous state.

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