Graft survival prolongation with porphyrins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514183, A61K 3133, A61K 31555

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active

057564922

ABSTRACT:
Metalloporphyrins are administered in conjunction with transplantation to enhance the survival of the organ.

REFERENCES:
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Willis, D., et al., "Heme Oxygenase: A Novel Target for the Modulation of the Inflammatory Response," Nature Medicine, 2(1):87-90 (1996).
Agarwal, A.,et al., "Gas-Generating Systems in Acute Renal Allograft Rejection in the Rat," Transplantation, 61:93-98 (1996).
Maines, M.D., "Zinc-Protoporphyrin in a Selective Inhibitor of Heme Oxygenase Activity in the Neonatal Rat," 673:339-350 (1981).
Drummond, G.S. and A. Kappas, "Preventioin of Neonatal Hyperbilirubinemia by Tin Protoporphyrin IX, a Potent Competitive Inhibitor of Heme Oxidation," Proc. Natl. Acad. Sci. USA, 78(10):6466-6470 (1981).
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