Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Digestive system
Patent
1991-09-24
1994-01-25
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Digestive system
623 11, 623 13, A61K 3538
Patent
active
052814220
ABSTRACT:
Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, muscularis mucosa and stratum compactum delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
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Comparison of Bovine Collagen Xenografts to Autografts in the Rabbit, J. C. Tauro, et al., Clinical Orthopaedics and Related Research, No. 266, May, 1991, pp. 271-284.
Development of a Reconstituted Collegen Tendon Prosthesis, Jack D. Goldstein, et al. The Journal of Bone and Joint Surgery, Incorporated, vol. 71-A, No. 8, Sep. 1989, pp. 1183-1191.
"Aortic Replacement With Multi-Layer Submucosa Prostheses Made From Heterologous Small Intestine", G. Rotthoff, et al., J. Cardiovas. Sur., pp. 31-35.
"Replacement Of The Abdominal Aorta By An Ileum Muscle Tube In An Animal Experiment", J. Huth, et al., Thoraxchir. Vask. Chir., 15(4): 401-407, Aug. 1967.
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"Replacement Of The Abdominal Aorta With A Small-Intestine Muscle Tube In An Animal Experiment", J. Huth, Zentralbl. Chir., 1817-19 (1967).
"Reconstruction Of The Arterial Flow Path By Autologous Intestinal Muscle Grafts In The Dog", Bruch, et al., Folia Angiologica, vol. 29 (3-5/81) pp. 65-68.
"Replacement Of The Aorta By Multilayered Submucosa Prostheses Of Heterologous Ileum", G. Rotthoff, et al., Bulletin De La Societe International de Chirurgia, No. 2, 1969, 256-259.
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Badylak Stephen F.
Coffey Arthur C.
Geddes Leslie A.
Lantz Gary C.
Shelbourne K. Donald
Purdue Research Foundation
Robinson Douglas W.
Witz Jean C.
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