Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2007-05-15
2007-05-15
Sisson, Bradley L. (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S288200, C435S288500, C435S288600, C422S050000, C422S068100, C422S091000, C536S023100
Reexamination Certificate
active
10414620
ABSTRACT:
The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.
REFERENCES:
patent: 5772905 (1998-06-01), Chou
patent: 5867266 (1999-02-01), Craighead
patent: 6083758 (2000-07-01), Imperiali et al.
patent: 6165688 (2000-12-01), Celotta et al.
patent: 6182733 (2001-02-01), McReynolds
patent: 6210896 (2001-04-01), Chan
patent: 6214246 (2001-04-01), Craighead
patent: 6263286 (2001-07-01), Gilmanshin et al.
patent: 6304318 (2001-10-01), Matsumoto
patent: 6309580 (2001-10-01), Chou
patent: 6334960 (2002-01-01), Wilson et al.
patent: 6355420 (2002-03-01), Chan
patent: 6403311 (2002-06-01), Chan
patent: 6438279 (2002-08-01), Craighead et al.
patent: 6440662 (2002-08-01), Gerwen et al.
patent: 6482742 (2002-11-01), Chou
patent: 6515751 (2003-02-01), Craighead et al.
patent: 6518189 (2003-02-01), Chou
patent: 6685841 (2004-02-01), Lopez et al.
patent: 6755621 (2004-06-01), Lopez et al.
patent: 2001/0014850 (2001-08-01), Gilmanshin et al.
patent: 2001/0045357 (2001-11-01), Broadley et al.
patent: 2002/0015149 (2002-02-01), Rahbar-Dehghan et al.
patent: 2002/0028451 (2002-03-01), Abbott et al.
patent: 2002/0039737 (2002-04-01), Chan et al.
patent: 2002/0042027 (2002-04-01), Chou et al.
patent: 2002/0072243 (2002-06-01), Craighead et al.
patent: 2002/0081744 (2002-06-01), Chan et al.
patent: 2002/0132482 (2002-09-01), Chou
patent: 2002/0160356 (2002-10-01), Craighead et al.
patent: 2002/0167117 (2002-11-01), Chou
patent: 2003/0012657 (2003-01-01), Marr et al.
patent: 2003/0012866 (2003-01-01), Harnett et al.
patent: 2003/0034329 (2003-02-01), Chou
patent: 2003/0080471 (2003-05-01), Chou
patent: 2003/0080472 (2003-05-01), Chou
patent: 2003/0170995 (2003-09-01), Chou
patent: 2003/0170996 (2003-09-01), Chou
patent: 2004/0197843 (2004-10-01), Chou et al.
patent: 2005/0023156 (2005-02-01), Ramsey et al.
patent: WO 00/09757 (2000-02-01), None
patent: WO 01/37958 (2001-05-01), None
patent: WO 02/07199 (2002-01-01), None
patent: WO 03/010289 (2003-02-01), None
patent: WO 03/079416 (2003-09-01), None
patent: WO 03/106693 (2003-12-01), None
Akeson, M., et al., “Microsecond time-scale discrimination among polycyctidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules,”Biophysical J., 1999, 77, 3227-3233.
Austin, R.H., et al., “Scanning the controls: genomics and nanotechnology,”IEEE Trans. On Nanotechnology, 2002, 1(1), 12-18.
Bakajin, O., “Separation of 100-kilobase DNA molecules in 10 seconds,”Anal. Chem., 2001, 73, 6053-6056.
Ball, P., “DNA combed into nanochannels,”NPG Nature Publishing Group, wysiwyg://6/http://www.nature.com, 2002, downloaded Nov. 27, 2002, 2 pages.
Bates, M., et al., “Dynamics of DNA molecules in a membrane channel probed by active control techniques,”Biophysical J., 2003, 84, 2366-2372.
Bhusari, D., et al., “Fabrication of air-channel structures for microfluidic, microelectromechanical, and microelectronic applications,”J. of Microelectromech. Syst., 2001, 10(3), 400-408.
Braslavsky, I., et al., “Sequence information can be obtained from single DNA molecules,”PNAS, 2003, 100(7), 3960-3964.
Cao, H., et al., “Fabrication of 10 nm enclosed nanofluidic channels,”Applied Physics Letters, 2002, 81(1), 174-176.
Cao, H., et al., “Gradient nanostructures for interfacing microfluidics and nanofluidics,”Applied Physics Letters, 2002, 81(16), 3058-3060.
Cao, H., “Sensors and Sensitivity,”Innovation, The Princeton Journal of Science and Technology, about late Fall, 2002, 28-31.
Chou, H.-P., et al., “A microfabricated device for sizing and sorting DNA molecules,”Proc. Nat. Acad. Sci. USA, 1999, 96, 11-13.
Chou, C.-F., et al, “Sorting by diffusion: an asymmetric obstacle course for continuous molecular separation,”PNAS, 1999, 96(24), 13762-13765.
Chou, S.Y., “Imprint lithography with 25-nanometer resolution,”Science, 1996, 272, 85-87.
Gerstner, E., “Put a lid on it!,”NPG Publishing Group, wysiwyg://12/http://www.nature.com, 2002, downloaded Jul. 4, 2002, 2 pages.
Han, J., et al., “Separation of long DNA molecules in a microfabricated entropic trap array,”Science, 2000, 288, 1026-1029.
Han, J., et al., “Characterization and optimization of an entropic trap for DNA separation,”Analytical Chem., 2002, 74, 394-401.
Han, J., et al., “From microfluidics to nanofluidics: DNA separation using nanofluidic entropic trap array device,”Proceedings of SPIE, 2000, vol. 4177, 42-48.
Harnett, C.K., et al., “Heat-depolymerizable polycarbonates as electron beam patternable sacrificial layers for nanofluidics,”J. Vac. Sci. Technol. B, Nov./Dec. 2001, 19(6), 2842-2845.
Henrickson, S.E., et al., “Driven DNA transport into an asymmetric nanometer-scale pore,”Physical Review Letters, 2000, 85(14), 3057-3060.
Ju, S.-P., et al., “Molecular dynamics simulation of sputter trench-filling morphology in damascene process,”J. Vac. Sci. Technol. B, May/Jun. 2002, 20(3), 946-955.
Kalaugher, L., “Diffraction gradient lithography aids nanofluidics,” IOP Publishers Nanotechnology, http:/
anotechweb.org., 2002, downloaded Oct. 22, 2003, 2 pages.
Kasianowicz, J.J., et al., “Characterization of individual polynucleotide molecules using a membrane channel,”Proc. Natl. Acad. Sci. USA, 1996, 93, 13770-13773.
Li, M., et al., “Fabrication of circular optical structures with a 20 nm minimum feature size using nanoimprint lithography,”Applied Physics Letts., 2000, 76(6), 673-675.
Li, J., et al., “Ion-beam sculpting at nanometer length scales,”Nature, 2001, 412, 166-169.
Li, W., et al., “Sacrificial polymers for nanofluidic channels in biological applications,”Nanotechnology, 2003, 14, 578-583.
Mason, J., “Princeton builds tiniest tunnel, reveals nanostamping process,”Smalltimes, www.smalltimes.com, download dated Oct. 22, 2003, 2 pages.
Masauda, H., et al., “Highly ordered nanochannel-array architecture in anodic alumina,”Am. Inst. Of Physics, 1997, 2770-2772.
Meller, A., et al., “Single molecule measurements of DNA transport through a nanopore,”Electrophoresis, 2002, 23, 2583-2591.
Meller, A., et al., “Voltage-driven DNA translocations through a nanopore,”Am. Physic. Soc., 2001, 86(15), 3435-3438.
Meller, A., “Dynamics of polynucleotide transport through nanometer-scale pores,”J. Phys. Condens. Matter, 2003, 15, R581-R607.
Meller, A., “Rapid nanopore discrimination between single polynucleotide molecules,”PNAS, 2000, 97(3), 1079-1084.
Quake, S.R., et al., “From micro- to nanofabrication with soft materials,”Science, 2000, 290, 1536-1540.
Riordan, T., “Patents: An obsession with DNA and the human genome leads to development of a technology,”New York Times, Mar. 18, 2002, 3 pages.
Schultz, S., “Discovery could lead to faster, smaller, cheaper computer chips,”Princeton University, http://www.princeton,edu, 2002, downloaded Oct. 22, 2003, 2 pages.
Soares, L.L., et al., “Fabrication of dielectric hollow submicrometric pipes,”J. Vac. Sci. Technol. B, 2000, 713-716.
Stern, M.B., et al., “
Austin Robert H.
Cao Han
Chou Stephen
Tegenfeldt Jonas O.
Princeton University
Sisson Bradley L.
Woodcock & Washburn LLP
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