GP 130 lacking the transmembrane domain

Details GP 130 lacking the transmembrane domain GP 130 lacking the transmembrane domain

1997-03-19

1999-10-12

Feisee, Lila

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 4353201, 435 691, 530350, C12N 1510, C12N 1512, C07K 14705

Patent

active

059657243

ABSTRACT:
A novel splice-variant of gp 130 is disclosed, together with DNA sequence coding for it, pharmaceutical formulations comprising it, and its use ensuring the correct development of pre-implantation embryos.

REFERENCES:
patent: 5132403 (1992-07-01), Kishimoto
patent: 5223611 (1993-06-01), Kishimoto
patent: 5426048 (1995-06-01), Gearing et al.
patent: 5783672 (1998-07-01), Mosley et al.
Geisterfer et al., Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, and gp130), Cytokine, 7(6):503-9, Aug. 1995.
Hibi et al., Molecular cloning and expression of an IL-6 signal transducer, gp130, Cell, 63: 1149-57, Dec. 1990.
Adamson, E.D., "Activities of Growth Factors in Preimplantation Embryos," J. Cell. Biochem. 53:280-287 (Dec. 1993).
Harvey, M.B., and Kaye, P.L., "Insulin-Like Growth Factor-1 Stimulates Growth of Mouse Preimplantation Embryos In Vitro," Mol. Reprod. Dev. 31:195-199 (1992).
Hill, J.A., et al., "Products of Activated Lymphocytes and Macrophages Inhibit Mouse Embryo Development in Vitro," J. Immunol. 139(7):2250-2254 (1987).
Lachapelle, M.H., et al., "Embryonic resistance to tumour necrosis factor-.alpha. mediated cytotoxicity: novel mechanism underlying maternal immunological tolerance to the fetal allograft," Human Reproduction 8(7):1032-1038 (Jul. 1993).
Narazaki, M., et al., "Soluble Forms of the Interleukin-6 Signal-Transducing Receptor Component gp130 in Human Serum Possessing a Potential to Inhibit Signals Through Membrane-Anchored gp130," Blood 82(4):1120-1126 (Aug. 1993).
Pampfer, S., et al., "Expression of Tumor Necrosis Factor-.alpha. (TNF.alpha.) Receptors and Selective Effect of TNF.alpha. on the Inner Cell Mass in Mouse Blastocysts," Endocrinology 134 (1):206-212 (Jan. 1994).
Rappolee, D.A., et al., "Developmental Expression of PDGF, TGF-.alpha., and TGF-.beta. Genes in Preimplantation Mouse Embryos," Science 241:1823-1825 (1988).
Schultz, G.A., and Heyner, S., "Gene expression in pre-implantation mammalian embryos," Mutation Research 296:17-31 (1992).
Sharkey, A.M., et al., "Stage-Specific Expression of Cytokine and Receptor Messenger Ribonucleic Acids in Human Preimplantation Embryos," Biol. Reprod. 53:974-981 (Oct. 1995).
Taga, T., et al., "Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130," Proc. Natl. Acad. Sci. USA 89:10998-11001 (1992).
Watson, A.J., et al., "A Growth Factor Phenotype Map for Ovine Preimplantation Development," Biol. Reprod. 50:725-733 (Apr. 1994).
Witkin, S.S., et al., "Tumor necrosis factor is present in maternal sera and embryo culture fluids during in vitro fertilization," J. Reprod. Immunol. 19:85-93 (1991).
Yasukawa, K., et al., "Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130," Immunology Letters 31:123-130 (1992).
Zolti, M., et al., "Cytokine involvement in oocytes and early embryos," Fertility and Sterility 56(2):265-272 (1991).
English language abstract of Japanese Patent No. 06-22786, Patent Abstracts of Japan 18(226):C-1194 (Apr. 1994).
Copy of the International Search Report for International Application No. PCT/GB95/02243.

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