Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1995-01-27
2000-09-05
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
514700, A61K 3112, A61K 3111
Patent
active
061143979
ABSTRACT:
A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method for treating cancer in a human which comprises administering to the human subject an anti-cancer effective amount of any of the compounds listed above in combination with an anti-cancer effective amount of other conventional chemotherapeutic agents. Finally, the invention also encompasses a pharmaceutical composition comprising an anti-cancer effective amount of gossypol, gossypol acetic acid, or gossypolone, and an anti-cancer effective amount of a conventional chemotherapeutic agent, or combinations of the latter.
REFERENCES:
Rao et al. (1985) Cancer Chemother. Pharmacol. 15:2-25.
Tanphaichitr et al. (1984) Biology of Reproduction 31:1049-1060.
Band et al., Gynecol. Oncol. (1989), 32(3), 273-7 (abstract only), 1989.
Rao et al, Cancer Chemother. Pharmacol, 15:20-25 1985.
Tso, Cancer Lett., 24: 257-261 1984.
Qian, Ann Rev Pharmacol, 24: 329-60 (1984).
Kim et al, Contraception 312 : 5966-72 (1984 .
Wu et al, Cancer Research 49, pp 3754-3758, Jul. 15, 1989.
Flack Mary R.
Knazek Richard
Reidenberg Marcus
Goldberg Jerome D.
The United States of America as represented by the Department of
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