Gossypol co-crystals and the use thereof

Details Gossypol co-crystals and the use thereof Gossypol co-crystals and the use thereof

2007-06-15

2008-10-07

Marschel, Ardin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S548000, C514S682000, C514S700000, C514S025000

Reexamination Certificate

active

07432300

ABSTRACT:
This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8carboxylic acid or C1-8sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8carboxylic acid or C1-8sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

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