Good-tasting gritty drug formulations

Details Good-tasting gritty drug formulations Good-tasting gritty drug formulations

1989-07-19

1992-04-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424439, 424441, 424501, 514974, 514948, 514951, A61K 968

Patent

active

051026643

ABSTRACT:
The application discloses a good-tasting and palatable gritty drug formulation, wherein the grittiness is associated as a part of a pleasurable organoleptic sensation, which contains a gritty and optionally bad-tasting or odoriferous drug and a seedy fibrous fruit, and optionally an aqueous medium and a gelling agent, and preferably also a sweetener and a flavoring agent, wherein the gritty drug is representatively an antihypercholesterolemic drug, especially a bile acid sequestrant, and particularly cholestyramine, a method for the preparation thereof, and a method of converting a gritty drug into a more readily-acceptable formulation which assists with patient compliance.

REFERENCES:
patent: 1598348 (1926-08-01), Hickey
patent: 3794741 (1974-02-01), Weigle
patent: 3974272 (1976-08-01), Polli et al.
patent: 4565702 (1986-01-01), Morley et al.
patent: 4747881 (1988-05-01), Shaw et al.
patent: 4851392 (1989-07-01), Shaw et al.
patent: 4950140 (1990-08-01), Pflauner et al.
"Low Density Lipoproteins", pp. 421-438, Plenum Press (1976).
C.A. 102: 84,412w (1985).
C.A. 108: 210,223z (1988).
C.A. 105: 12,144z (1986).
C.A. 108: 26,960m (1988).
C.A. 100: 109,108a (1984).

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