Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1995-11-09
1997-11-25
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530397, 530324, 530850, 514 2, 514 8, 514 12, A61K 3824, A61K 3800, C07K 1459, C07K 1400
Patent
active
056914555
ABSTRACT:
The present invention relates to gonadotropins consisting of an .alpha. and .beta. subunit, said gonadotropins comprising non-native disulfide bridges, preferably non-native intersubunit disulfide bridges. The gonadotropins according to the invention have improved stability. The present invention furthermore provides for pharmaceutical compositions comprising said gonadotropins.
REFERENCES:
Bedow, E. et al. Kinetics of folding and assembly of the human chorionic gonadotropin b subunit in transfected chinese hamster ovary cells. J. Biol. Chemistry, 267 (13) 8880-8886, 1990.
H. Xia et al., Journal of Biological Chemistry, 269:27:17944-17953, 1994.
Grootenhuis Pieter Diederik Jan
Heikoop Judith Christina
Akzo Nobel N.V.
Borin Michael
Gormley Mary E.
Tsang Cecilia J.
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