Gonadotropins with non-native disulfide bridges

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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530397, 530324, 530850, 514 2, 514 8, 514 12, A61K 3824, A61K 3800, C07K 1459, C07K 1400

Patent

active

056914555

ABSTRACT:
The present invention relates to gonadotropins consisting of an .alpha. and .beta. subunit, said gonadotropins comprising non-native disulfide bridges, preferably non-native intersubunit disulfide bridges. The gonadotropins according to the invention have improved stability. The present invention furthermore provides for pharmaceutical compositions comprising said gonadotropins.

REFERENCES:
Bedow, E. et al. Kinetics of folding and assembly of the human chorionic gonadotropin b subunit in transfected chinese hamster ovary cells. J. Biol. Chemistry, 267 (13) 8880-8886, 1990.
H. Xia et al., Journal of Biological Chemistry, 269:27:17944-17953, 1994.

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