Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-26
2005-07-26
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252010, C544S238000, C544S247000
Reexamination Certificate
active
06921761
ABSTRACT:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
REFERENCES:
patent: 5780437 (1998-07-01), Goulet et al.
patent: 5849764 (1998-12-01), Goulet et al.
patent: WO 96/38438 (1996-12-01), None
patent: WO 97/14682 (1997-04-01), None
patent: WO 97/14697 (1997-04-01), None
patent: WO 97/21435 (1997-06-01), None
patent: WO 97/21703 (1997-06-01), None
patent: WO 97/21704 (1997-06-01), None
patent: WO 97/21707 (1997-06-01), None
patent: WO 97/44037 (1997-11-01), None
patent: WO 97/44041 (1997-11-01), None
patent: WO 97/44321 (1997-11-01), None
patent: WO 97/44339 (1997-11-01), None
patent: WO 98/55116 (1998-12-01), None
patent: WO 98/55119 (1998-12-01), None
patent: WO 98/55470 (1998-12-01), None
patent: WO 98/55479 (1998-12-01), None
patent: WO 99/09033 (1999-02-01), None
patent: WO 99/33831 (1999-07-01), None
patent: WO 00/56739 (2000-09-01), None
patent: WO 01/29044 (2001-04-01), None
patent: WO 01/55119 (2001-08-01), None
Wolft Manfred E. “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.”, Marcel Dekker, New York. 1996, pp. 451 and 596.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
Huirne, JA, and Lambalk, GB., Lancet 358(9295: 1793-1803, 2001.
Cho et al., “Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor,”J Med Chem. 41(22): 4190-4195, Oct. 22, 1998.
Huirne, J., et al.,Lancet 358(9295):1793-1803, 2001.
Chen Chen
Guo Zhiqiang
Rowbottom Martin
Wu Dongpei
Balasubramanian Venkataraman
Neurocrine Biosciences Inc.
Seed IP Law Group PLLC
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