Gonadotropin-releasing hormone receptor antagonists and...

Details Gonadotropin-releasing hormone receptor antagonists and... Gonadotropin-releasing hormone receptor antagonists and...

2008-04-04

2011-12-27

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S348000, C564S183000, C514S352000

Reexamination Certificate

active

08084614

ABSTRACT:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

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