Gonadostatin

Details Gonadostatin Gonadostatin

1981-08-10

1983-10-11

Lieberman, Allan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125LH, C07G 1500

Patent

active

044091397

ABSTRACT:
A substantially purified substance has been isolated from bovine gonadal secretions which mediates pituitary hormone secretion, using an extraction and purification sequence that includes gel filtration, partition chromatography and HPLC in that order. The substance, designated gonadostatin, is a moderate-size peptide which below a threshold level selectively inhibits LRF-stimulated pituitary secretion of LH and FSH. Above a threshold level, gonadostatin generally stimulates pituitary hormone secretion.

REFERENCES:
Franchimont P. et al., Vitamins and Hormones, vol. 37, 1979, pp. 243-302.
De Jong and Sharpe, Nature, vol. 263, pp. 71-72, 1976.
Steinberger and Steinberger, Endocrinology 99: 918-921, 1976.
Chari S. et al., Acta Endocrinologica 87: 434-448, 1976.
Franchimont et al., Nature, vol. 257, pp. 402-404, 1975.
De Jong et al., J. Endocrinology 80: 91-102, 1979.
Ying et al., Bioregulators of Reproduction, pp. 389-401, 1981.

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