Gona-4,9(10)-dienes and process of producing the same

Details Gona-4,9(10)-dienes and process of producing the same Gona-4,9(10)-dienes and process of producing the same

1979-02-13

1981-02-03

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955R, 260349, C07C11700, C07J 1700

Patent

active

042487900

ABSTRACT:
New gona-4,9(10)-dienes of formula I ##STR1## where R is alkyl of 1 to 3 carbon atoms and X is Cl, Br, F, N.sub.3, SCN, CN, OH, OR'(R'-alkyl), NH.sub.2, a substituted amino group or a heterocyclic compound including nitrogen in the ring. The compounds have valuable biological properties, especially hormonal and antihormonal effects, and can be used to advantage in pharmaceutical preparation, for the treatment of endocrinopathies and for reproduction control in human beings and livestock.
The invention also embraces a process for making the compounds by converting 3-methoxy-13.beta.-R-gona-2,5(10)-diene-17.beta.-spiro-1,`2`-ox iranes to 17.beta.-hydroxy-17.alpha.-CH.sub.2 -13.beta.-R-gona-4,9(10)-diene-3-ones to the 17.alpha.-CH.sub.2 X-14.beta.-ols which are hydrolyzed to the 17.beta.-OH which latter are then converted to the compounds of formula I.

REFERENCES:
patent: 3502699 (1970-03-01), Hughes et al.
patent: 3931154 (1976-01-01), Phillippson et al.
patent: 4029648 (1977-06-01), Ponsold et al.

Affiliated with

Also associated with

Rating

Gona-4,9(10)-dienes and process of producing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gona-4,9(10)-dienes and process of producing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gona-4,9(10)-dienes and process of producing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-550402