Golfomycin derivatives: fused ring cyclodecadiyne derivatives ha

Details Golfomycin derivatives: fused ring cyclodecadiyne derivatives ha Golfomycin derivatives: fused ring cyclodecadiyne derivatives ha

1990-08-01

1992-08-04

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568326, 544344, 546 93, 546183, 548217, 548369, 548452, 549 52, 549 44, 549458, 549471, C07C 49223

Patent

active

051360993

ABSTRACT:
5-Hydroxy-benzo-(1',2')-cyclodeca-2,7-diyne-1-one and derivatives thereof and related fused ring diyneone macrocyclic compounds are disclosed. The compounds possess DNA-cleaving, antibiotic and tumor growth-inhibiting properties. Methods of making and using the same are also disclosed.

REFERENCES:
Nicolaou et al., J.A.C.S., vol. 110, p. 7247 (1988).
Povsic et al. J.A.C.S., vol. 111, p. 3059 (1989).
Hertzberg et al., J.A.C.S., vol. 104, p. 313 (1982).
Pyle et al., J.A.C.S., vol. 111, p. 4520 (1989).

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