Radiant energy – Ionic separation or analysis – Ion beam pulsing means with detector synchronizing means
Reexamination Certificate
2005-09-21
2009-12-08
Vanore, David A. (Department: 2881)
Radiant energy
Ionic separation or analysis
Ion beam pulsing means with detector synchronizing means
C250S282000, C250S309000
Reexamination Certificate
active
07629576
ABSTRACT:
The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
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Supplementary European Search Report issued during the prosecution of European Application No. 04 75 4363.
Egan Thomas F.
Le Beyec Yvon
Negra Serge D.
Schultz J. Albert
Tempez Agnes
Fulbright & Jaworski L.L.P.
Ionwerks, Inc.
Johnston Phillip A.
Vanore David A.
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