Radiant energy – Ionic separation or analysis
Reexamination Certificate
2006-01-24
2006-01-24
Lee, John R. (Department: 2881)
Radiant energy
Ionic separation or analysis
C250S282000, C250S287000, C250S288000
Reexamination Certificate
active
06989528
ABSTRACT:
The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
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Della-Negra Serge
Egan Thomas F.
Le Beyec Yvon
Schultz J. Albert
Tempez Agnes
Fulbright & Jaworski LLP
Gurzo Paul M.
Ionwerks, Inc.
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