GNRH-leukotoxin chimeras

Details GNRH-leukotoxin chimeras GNRH-leukotoxin chimeras

1997-06-19

1999-10-19

Minnifield, Nita

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 234, 536 237, 435 691, 435 693, 435 697, 4351721, 4351723, C07H 204, C07H 202, C12P 2106, A61K 3902

Patent

active

059691263

ABSTRACT:
New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected GnRH multimer which consists essentially of at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimer fused thereto.

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