Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-07-29
2000-02-08
Minnifield, Nita
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 234, 536 237, 4241841, 4242351, 4353201, 4352523, 435 693, 435 697, 4351721, 4351723, C07H 204, C07H 202, C12P 2106, A61K 3900
Patent
active
060229608
ABSTRACT:
New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.
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Manns John G.
Potter Andrew A.
Minnifield Nita
University of Saskatchewan
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