Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-07-26
1984-04-24
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125LH, C07C10352, A61K 3702
Patent
active
044447590
ABSTRACT:
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gondads. The peptides have the structure.
X-.beta.-D-2NAL-R.sub.2 -D-Trp-Ser-R.sub.5 -R.sub.6 -R.sub.7 -Arg-Pro-R.sub.10 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R.sub.2 is Cl-D-Phe, F-D-Phe, NO.sub.2 -D-Phe, Cl.sub.2 -D-Phe or Br-D-Phe; R.sub.5 is Tyr or Cl-Phe; R.sub.6 is 4-NH.sub.2 -D-Phe or D-Arg; R.sub.7 is Leu or N.alpha.Me-Leu; and R.sub.10 is Gly-NH.sub.2, NHCH.sub.2 CH.sub.3 or D-Ala-NH.sub.2.
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C. W. Beattie, et al., J. of Med. Chem. (1975) vol. 18, No. 12, pp. 1247-1250.
Peptide Antagonists of LH-RH: Large Increases in Antivulatory Activities Produced by Basic D-Amino Acids in the 6-Position, Endocrinology pp. 1445-1447.
Rivier Jean E. F.
Vale, Jr. Wylie W.
Moezie F. T.
Phillips Delbert R.
The Salk Institute for Biological Studies
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