Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-04-21
1983-10-11
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125LH, A61K 3700, C07C10352
Patent
active
044092083
ABSTRACT:
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure.
REFERENCES:
patent: 3933782 (1976-01-01), Yardley et al.
patent: 4234571 (1980-11-01), Nestor et al.
patent: 4253997 (1981-03-01), Sarantakis
Journal of Medicinal Chemistry, 18, (1975), 1247-1250.
Biochem. and Biophys. Res. Comm., vol. 66, No. 1, (1975), pp. 336-343, Prasad et al., "Synthesis and Biological Activity of Antagonists of Luteinizing Hormone-Releasing Hormone, (LH-RH).
Chemical Pharm. Bull., vol. 24, No. 12, pp. 3149-3157, (1976) Yabe et al., "Analogues of Luteinizing Hormone-Releasing Hormone with Modification in Position 3.sup.1 ".
Rivier Jean E. F.
Vale, Jr. Wylie W.
Phillips Delbert R.
The Salk Institute for Biological Studies
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