Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-02-14
1995-01-03
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 14, 514 16, 530313, 530324, 530328, 530326, A61K 3700, A61K 3702, C07K 500, C07K 700
Patent
active
053786882
ABSTRACT:
Certain toxic compounds (T) such as, for example, compounds based upon diphtheria toxin, ricin toxin, pseudomonas exotoxin, .alpha.-amanitin, pokeweed antiviral protein (PAP), ribosome inhibiting proteins, especially the ribosome inhibiting proteins of barley, wheat, corn, rye, gelonin and abrin, as well as certain cytotoxic chemicals such as, for example, melphalan and daunomycin can be conjugated to certain analogs of gonadotropin-releasing hormone to form a class of compounds which, when injected into an animal, destroy the gonadotrophs of the animal's anterior pituitary gland. Hence such compounds may be used to sterilize such animals and/or to treat certain sex hormone related diseases.
REFERENCES:
patent: 4691006 (1987-09-01), Stevens
patent: 4767842 (1988-08-01), Stevens
Myers et al., Biochem J., vol. 227 No. 1, p. 343, (1985).
Singh et al., Int. J. Pharm., vol. 76, R5-R8, 1991.
Bacha et al., "Organ-Specific Binding of a Thyrotropin-Releasing Hormone-Diphtheria Toxin Complex after Intravenous Administration to Rats", pp. 1072-1076, 1983, Endocrinology, vol. 113.
Bacha et al., "Systemic Toxicity of Diphtheria Toxin-Related Fragments (CRM26, CRM45), a Hormone-Toxin Hybrid Protein (TRH-CRM45), and Ricin A.sup.1 (42234)", pp. 131-138, 1986, Proc. Soc. Exp. Biol. Med., vol. 181.
Bacha et al., "Thyrotropin-Releasing Hormone-Diphtheria Toxin-Related Polypeptide Conjugates; Potential Role of the Hydrophobic Domain in Toxin Entry", pp. 1565-1570, 1983 J. Biol. Chem., vol. 258, Feb.
Bourdon et al., "The Potential of Monoclonal Antibodies as Carriers of Radiation and Drugs for Immunodetection and Therapy of Brain Tumors", pp. 79-101, 1984, Prog. exp. Tumor Res., vol. 28.
Cawley et al., "Epidermal Growth Factor-Toxin A Chain Conjugates: EGF-Ricin A is a Potent Toxin While EGF-Diphtheria Fragment A is Nontoxic", pp. 563-570, 1980, Cell, vol. 22, Nov.
Chang et al., "Artificial Hybrid Protein Containing a Toxic Protein Fragment and a Cell Membrane Receptor-Binding Moiety in a Disulfide Conjugate", pp. 1515-1522, 1977, J. Biol. Chem., vol. 252, Feb.
Chaudhary et al., "Activity of a Recombinant Fusion Protein Between Transforming Growth Factor Type .alpha. and Pseudomonas Toxin", pp. 4538-4542, 1987, Proc. Natl. Acad. Sci. USA, vol. 84, Jul.
Colombatti et al., "Cloned Fragment of Diphtheria Toxin Linked to T Cell-Specific Antibody Identifies Regions of B Chain Active in Cell Entry", pp. 3030-3035, 1986, J. Biol. Chem., vol. 261, Mar.
Greenfield et al., "Mutations in Diphtheria Toxin Separate Binding from Entry and Amplify Immunotoxin Selectivity", pp. 536-539, 1987, Science, vol. 238, Oct.
Murphy et al., "Genetic Construction, Expression, and Melanoma-Selective Cytotoxicity of a Diphtheria Toxin-Related .alpha.-Melanocyte-Stimulating Hormone Fusion Protein", pp. 8258-8262, 1986, Proc. Natl. Acad. Sci. USA, vol. 83, Nov.
Myers, "Hybrid Toxins: An Approach to Cell Specific Toxicity", 1987, Dissertation submitted to the Division of Animal Science and the Graduate School of the University of Wyoming, Laramie, Wyoming.
Oeltmann et al., "A Hybrid Protein Containing the Toxic Subunit of Ricin and the Cell-Specific Subunit of Human Chorionic Gonadotropin", pp. 1028-1032, 1979, J. Biol. Chem., vol. 4, Feb.
Oeltmann, "Synthesis and In Vitro Activity of a Hormone-Diphtheria Toxin Fragment of a Hybrid", pp. 430-435, 1985, Biochem. Biophys. Res. Commun., vol. 133, Dec.
Pastan et al., "Immunotoxins", pp. 641-648, Cell, vol. 47, Dec.
Schwartz et al., "A New Cytotoxin Specific for the Target Cells of Corticotropin-Releasing Factor", pp. 1454-1460, 1987, Endocrinology, vol. 121.
Vitetta et al., "Redesigning Nature's Poisons to Create Anti-Tumor Reagents", pp. 1098-1104, 1987, Science, vol. 238, Nov.
Youle et al., "Immunotoxins Show Rapid Entry of Diphtheria Toxin but not Ricin via the T3 Antigen", pp. 93-98, 1986, J. Immunol., vol. 136, Jan.
Myers, D. A., Murdock, W. J. and Villemez, C. L., Protein-Peptide Conjugation By A Two-Phase Reaction: Biochem J., 227:1 p. 343 (1985).
International Journal Of Pharmacology, 76: R5-R8, Singh et al--"Controlled Release Of LHRH-DT From Bioerodible Hydrogel Microspheres".
Glode Leonard M.
Nett Torrance M.
Colorado State University Research Foundation
Davenport A. M.
Hill Jr. Robert J.
LandOfFree
GnRH analogs for destroying gonadotrophs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with GnRH analogs for destroying gonadotrophs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and GnRH analogs for destroying gonadotrophs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2211527