gM-negative EHV-mutants

Details gM-negative EHV-mutants gM-negative EHV-mutants

2007-12-18

2007-12-18

Campell, Bruce R. (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S005000, C435S006120, C435S007100, C424S184100, C424S204100, C424S229100, C530S300000, C530S350000

Reexamination Certificate

active

10673017

ABSTRACT:
This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.

REFERENCES:
patent: 5922327 (1999-07-01), Crabb et al.
Neubauer et al., Equine Herpesvirus 1 mutants devoid of glycoprotein B or M are apathogenic for mice but induce protection against challenge infection, Virology, 1997, vol. 239, pp. 36-45.
Osterrieder et al., Synthesis and processing of the Equine Herpesvirus 1 glycoprotein M, Virology, 1997, vol. 232, pp. 230-239.
Osterrieder et al., The Equine Herpesvirus 1 glycoprotein gp21/22a, the Herpes Simplex Virus type 1 gM homolog, is involved in virus penetration and cell-to-cell spread of virions, Journal of Virology, Jun. 1996, vol. 70, No. 6, pp. 4110-4115.
Neubauer, A. et al: “Equine herpesvirus 1 mutants devoid of glycorprotein B or M are apathogenic for mice but induce protection against challenge infection.”, Virology (Dec. 1997), 239(1):36-45.
Osterrieder, N. et al: The Equine Herpesvirus 1 Glycoprotein gp21/22a, the Herpes Simplex Virus Type 1 gM Homolog, is involved in Virus Penetration and Cell-to Cell Spread of Virions, J. of Virol., 70(6):4110-4115, Jun. 1996.
Seyboldt, C. et al: “Equine herpesvirus 1 (EHV-1) glycoprotein M: Effect of deletions of transmembrane domains”; Virology, (Dec. 2000) 278 (2):477-489.
Osterrieder, et al; Deletion of gene 52 encoding glycoprotein M of equine herpesvirsu type 1 strain RacH results in increased immunogenicity; Veterinary Microbiology; vol. 81 (2001) pp. 219-226; Elsevier.

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