Glyoxal-2-oxim derivatives and a process for relieving pain/or i

Details Glyoxal-2-oxim derivatives and a process for relieving pain/or i Glyoxal-2-oxim derivatives and a process for relieving pain/or i

1979-03-02

1980-07-15

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548247, C07D26108, A61K 3142

Patent

active

042128749

ABSTRACT:
Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.

REFERENCES:
patent: 2772280 (1956-11-01), Peck et al.
Slater, "J. Chem. Soc.," vol. 117, (1920), pp. 587-591.
Kano et al., "J. Med. Chem.," vol. 10, (1967), pp. 411-418.

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