Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2008-01-29
2008-01-29
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
Reexamination Certificate
active
07323316
ABSTRACT:
This invention provides potent inhibitors of glycosyltransferases. The glyscosyltransferase inhibitors are useful for inhibiting the synthesis of glycosides. Accordingly, the glycosyltransferase inhibitors find use, for example, in the modulation of biological processes that involve glycoside-mediated cell adhesion.
REFERENCES:
Rabina et al. Analytical Biochemistry 1997;246:71-78.
Sousa et al. Cell Mol Biol 1996;42:609-616.
Chung et al. Biooranic & Medicinal Chemistry Letters 1998;8:3359-3364.
Sambandam et al. Archives of Biochem and Biophysics 1987;254(2):579-585.
Inokuchi, J-I, et al., “Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase,”Journal of Lipid Research, 1987, pp. 565-571, vol. 28, Bethesda, MD, US.
Kato, S. et al., “Inhibition of lipid-linked oligosaccharide synthesis by aryl phosphates,”The Biochemical Journal, Apr. 15, 1981, pp. 71-79, vol. 196, No. 1, The Biochemical Society, London.
Lee, L., et al., “Improved Inhibitors of Glucosylceramide Synthase,”The Journal of Biological Chemistry, May 21, 1999, pp. 14662-14669, vol. 274, No. 21, American Society for Biochemistry and Molecular Biology, Inc., Baltimore, MD, US.
Mead, R., et al. “Inhibition of Purified Rabbit Muscle Phosphorylaseaand Phosphorylasebby Polychlorinated Biphenyls, Polychlorinated Biphenylols and Polybrominated Biphenyls,”Biochimica et Biophysica Acta, 1982, pp. 173-179, vol. 701, No. 2, Elsevier Biomedical Press.
Mitranic, M., et al., “The Effect of Linoleic Acid and Benzyl Alcohol on the Activity of Glycosyltransferases of Rat Liver Golgi Membranes and Some Soluable Glycosltransferases,”Biochimica et Biophysica Atca, 1982, pp. 75-84, vol. 693, No. 1, Elsevier Biomedical Press.
Olshefski, R., et al, “Synthesis, Shedding, and Intercellular Transfer of Human Medulloblastoma Gangliosides: Abrogation by a New Inhibitor of Glucosylceramide Synthase,”Journal of Neurochemistry, 1998, pp. 467-472, vol. 70, No. 2, Lippincott-Raven Publishers, Philadelphia, PA, US.
Scudder, P., et al., “Glycosyltransferases of the Human Cervical Epithelium I. Characterization of a β-Galactoside α-2-L-Fucosyltransferase and the Identification of a β-N-Acetylclucosaminide α-3-L-Fucosyltransferase,”Biochimica et Biophysica Acta, 1981, pp. 128-135, vol. 660, No. 1, Elsevier/North-Holland Biomedical Press.
Shimizu, T., et al., “Partial Purification and Characterization of UDPG:t-Cinnamate Glucosyltransferase in the Root of Sweet Potato,Ipomoea batatasLam,”J. Biochem, 1984, pp. 205-212, vol. 95, No. 1.
Tudek, B., et al., “Activity ofEscherichia coliDNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives,”Mutation Research, 1998, pp. 169-176, vol. 407, No. 2, Elsevier.
Vunnam, R., et al., “Anaglos of Ceramide That Inhibit Glucocerebroside Synthetase in Mouse Brain,”Chemistry and Physics of Lipids, 1980, pp. 265-278, vol. 26, Elsevier/North-Holland scientific Publishers, Ltd.
Warren, K., et al., “Glycosyltransferases of Rat Brain that Make Cerebrosides: Substrate Specificity, Inhibitors, and Abnormal Products,”Journal of Neurochemistry, 1976, pp. 1063-1072, vol. 26, Pergamon Press, UK.
Wiewig, G., et al., “Dependence of Starch Synthase Activity From Maize Leaves on Light, pH and Redox State,”Acta Physiologica Latino Americana, 1976, pp. 415-423, vol. 26, No. 5.
Database Biosis Online!: Thaniyavarn, S., et al., “Pyridine Analogs Inhibit the Glucosyl Transferase EC-2.4.1.5 of Streptococcus-Mutans,”Infection and Immunity, 1982, 1 page, Bioscience Information Service, Philadelphia, PA, US.
Ichikawa, Yoshitaka, et al. “Chemical-Enzymatic Synthesis and Conformational Analysis of Sialyl Lewis x and Derivatives”,J. Am. Chem. Soc.(1992) 114:9283-9298.
Wong, Chi-Huey, et al. “Specificity, Inhibition and Synthetic Utility of a Recombinant Human α-1,3, Fucosyltransferase”,J. Am. Chem. Soc.(1992) 114:7231-7322.
Qiao, Lei, et al. “Synergistic Inhibition of Human α-1,3, Fucosyltransferase V”,J. Am. Chem. Soc.(1996) 118:7653-7662.
Chatterjee, Subroto, “Oxidized low density lipoproteins and lactosylceramide both stimulate the expression of proliferating cell nuclear antigen and the proliferation of aortic smooth muscle cells”Indian Journal of Biochemistry&Biophysics, (1997) 34:56-60.
Takayama, Suichi, et al. “Selective Inhibition of β-1,4- and α-1,3-Galactosyltransferases: Donor Sugar-Nucleotide Based Approach”,Bioorganic&Medicinal Chemistry(1999) 7:401-409.
Broquet, Pierre, et al. “Effect of Desipramine on a Glycoprotein Sialyltransferase Activity in C6 Cultured Glioma Cells”,Journal of Neurochemistry, (1990) 54(2):388-394.
Abaron Biosciences, Inc.
Gitomer Ralph
Shen Bin
Townsend and Townsend / and Crew LLP
LandOfFree
Glycosyltransferase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycosyltransferase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosyltransferase inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2808354