Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1997-09-05
1998-10-13
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
536 232, 4351723, 4352523, 43525233, 435712, 435 74, 435 78, C12N 1554, C12N 910, C12N 1563, C12N 121
Patent
active
058210989
ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed heterologous host cells for expressing the GtfD protein, and methods for producing glycopeptide compounds using the cloned gtfD gene.
REFERENCES:
S. K. Chung, et al. "Biosynthetic Studies f Aridicin Antibiotics: Microbial Transformations and Glycosylations by Protoplasts." Journal of Antibiotics 39(5):652-659 (May 1986).
M. J. Zmijewski, Jr., and B. Briggs. "Biosynthesis of vancomycin: identification of TDP-glucose: aglycosyl-vancomycin glucosyltransferase from Amycolatopsis orientalis." FEMS Microbiology Letters 5:129-134 (1989).
M. J. Zmijkjewski, Jr., and J. T. Fayerman. Genetics and Biochemistry of Antibiotic Production Ed. L.C. Vining and C. Stuttard. Butterworth Heinemann, Boston. Chapter 18: "Glycopeptide Antibiotics."pp. 71-83 (1985) .
Baltz Richard H.
Solenberg Patricia J.
Boone David E.
Eli Lilly and Company
Prouty Rebecca E.
Webster Thomas D.
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