Glycosyltransferase gene gtfb from Amycolatopsis orientalis

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

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4353201, 4352523, 43525411, 435325, 536 232, C12N 910, C12N 1500, C12N 120, C07H 2104

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active

058211004

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.

REFERENCES:
S. K. Chung, et al. "Biosynthetic Studies f Aricidin Antibiotics: Microbial Transformations and Glycosylations by Protoplasts." Journal of Antibiotics 39(5):652-659 (May 1986).
M. J. Zmijewski, Jr., and B. Briggs. "Biosynthesis of vancomycin: identification of TDP-glucose: aglycosyl-vancomycin glucosyltransferase from Amycolatopsis orientalis." FEMS Microbiology Letters 5:129-134 (1989).
M. J. Zmijewski, Jr., and J. T. Fayerman. Genetic and Biochemistry of Antibiotic Production Ed. L.C. Vining and C. Stuttard. Butterworth Heinemann, Boston. Chapter 18: "Glycopeptide Antibiotics." pp. 71-83 (1995).

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