Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1997-09-05
1998-10-13
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4353201, 4352523, 43525411, 435325, 536 232, C12N 910, C12N 1500, C12N 120, C07H 2104
Patent
active
058211004
ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.
REFERENCES:
S. K. Chung, et al. "Biosynthetic Studies f Aricidin Antibiotics: Microbial Transformations and Glycosylations by Protoplasts." Journal of Antibiotics 39(5):652-659 (May 1986).
M. J. Zmijewski, Jr., and B. Briggs. "Biosynthesis of vancomycin: identification of TDP-glucose: aglycosyl-vancomycin glucosyltransferase from Amycolatopsis orientalis." FEMS Microbiology Letters 5:129-134 (1989).
M. J. Zmijewski, Jr., and J. T. Fayerman. Genetic and Biochemistry of Antibiotic Production Ed. L.C. Vining and C. Stuttard. Butterworth Heinemann, Boston. Chapter 18: "Glycopeptide Antibiotics." pp. 71-83 (1995).
Baltz Richard H.
Solenberg Patricia J.
Boone David E.
Eli Lilly and Company
Hobbs Lisa J.
Prouty Rebecca E.
Webster Thomas D.
LandOfFree
Glycosyltransferase gene gtfb from Amycolatopsis orientalis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycosyltransferase gene gtfb from Amycolatopsis orientalis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosyltransferase gene gtfb from Amycolatopsis orientalis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-312523