Glycosyltransferase gene GtfA from Amycolatopsis orientalis

Details Glycosyltransferase gene GtfA from Amycolatopsis orientalis Glycosyltransferase gene GtfA from Amycolatopsis orientalis

1997-09-05

1998-10-13

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 6, 4353201, 4352523, 43525411, 435325, 536 232, C12N 910, C12N 1500, C12N 120, C07H 2104

Patent

active

058210997

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.

REFERENCES:
S. K. Chung, et al. "Biosynthetic Studies f Aridicin Antibiotics: Microbial Transformations and Glycosylations by Protoplasts." Journal of Antibiotics 39(5):652-659 (May 1986).
M. J. Zmijewski, Jr., and B. Briggs, "Biosynthesis of vancomycin: identification of TDP-glucose: aglycosyl-vancomycin glucosyltransferase from Amycolatopsis orientalis." FEMS Microbiology Letters 5:129-134 (1989).
M. J. Zmijewski, Jr., and J. T. Fayerman. Genetic and Biochemistry of Antibiotic Production Ed, L.C. Vining and C. Stuttard. Butterworth Heinemann, Boston. Chapter 18: "Glycopeptide Antibiotics." pp. 71-83 (1995).
Adams et al. EST07295 Homo sapiens cDNA clone HIBBT85 5' end, EST Database Accession No. T09402, Date Submitted Aug. 7, 1993.
Adams et al. (1993) Rapid cDNA Sequencing (Expressed Sequence Tags) From a Directionally Cloned Human Infant Brain cDNA Library. Nature Genetics 4:373-380.

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