Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-11-03
2000-06-20
Lee, Howard C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 291, 536 55, 536124, 530395, 530407, 530417, C07H 100, C07H 506
Patent
active
060779519
ABSTRACT:
The present invention consists in methods of preparing derivatives either isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilising reducing sugars onto solid supports and methods to obtain sugars from glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid-phase Edman degradation followed by separating and characterizing the sugars.
REFERENCES:
patent: 4021542 (1977-05-01), Schmidt et al.
patent: 5831077 (1998-11-01), Redmond et al.
Carlsson, Sven. "Isolation and Characterization of Glycoproteins" from Glycobiology: A Practical Approach edited by Minoru Fukuda and Akira Kobata, IRL Press, pp. 13-23, 1993.
Manzi et al. "Compositional analysis of glycoproteins", ibid., pp. 28, 29 and 50-53, 1993.
Montreuil et al. "Glycoproteins" from Carbohydrate Analysis: A Practical Approach (Second Edition) edited by M.F. Chaplin and J.F. Kennedy, IRL Press, pp. 188-205, 1994.
JP 02 038 858 A (Nat. Sci Counc. China); Feb. 8, 1990; Abstract.
Barba, et al., Diisothiocyanatopolystyrene and some of its polymer-analogous transformations., Chemical Abstracts 89(16):130113n 2,4, 1978.
Gooley, et al., Glycosylation Sites Identified by Detection of Glycosylated Amino Acids Released from Edman Degradation: The Identification of Xaa-Pro-Xaa-Xaa as a Motif for Thr-O-Glycosylation, Biochemical and Biophysical Research Communications, 178(3):1194, 1991.
Gooley, et al., Characterization of a single glycosylated asparagine site on a glycpeptide using solid-phase Edman degradation, Glycoconjugate Journal, 11:180, 1994.
Haas, et al., Rates of Reaction of Nitrogen Bases with Sugars I. Studies of Aldose Oxime, Semicarbazone and Hydrazone Formation, 84:4910, 1962.
Jezo, et al., Aminolysis of sucrose. IX. Reactions of sucrose with aqueous hydrazine solutions at elevated temperatures, 33 Carbohydrates, 66:11145, 11142u, 1967.
Pisano, et al., Glycosylation sites identified by solid-phase Edman degradation: O-linked glycosylation motifs on human glycophorin A, Glycobiology, 3(5):429, 1993.
Schmidt, et al., Synthese von Pyrazol-, Pyrazolo[3,4-d] pyrimidin-und 1H-1,2,4-Triazolgluconucleosiden aus Glucosehydrazonen, Liebigs Ann. Chem., pp. 2309-2317, 1981.
Strel'sova, et al., Synthesis of pyrazole N-glycosides, 33-Carbohydrates, 119-1147, 95943x, 1993.
Settineri, et al., Characterization of O-Glycosylation Sites in Recombinant B-Chain of Platelet-derived Growth Factor Expressed in Yeast Using Liquid Secondary Ion Mass Spectrometry, Tandem Mass Spectrometry and Edman Sequence Analysis, Biomedican and Environmental Mass Spectrometry, 19:665, 1990.
Stroh, et al., Uber die Reaktionsprodukte des Hydrazins mit Zuckern, Eingeganen am 7, pp. 1404, 1964.
Takasaki, et al., Hydrazionolysis of Asparagine-Linked Sugar Chains to Produce Free Oligosaccharides, Methods in Enzymology, 83:263, 1982.
Talbo, et al., Determination of the convalent structure of an N- and C-terminally blocked glycoprotein from endocuticle of Locusta migratoria, Eur. J. Biochem., 195:495, 1991.
Williams, J.M., Tautomerism of Saccharide Hydrazones in Solution and their Reaction with Nitrous Acid, Carbohydrate Research, 117:89, 1983.
Batley Michael
Cooper Catherine Anne
Gooley Andrew Arthur
Kett Warren Charles
Packer Nicolle Hannah
Haile Lisa A.
Lee Howard C.
LandOfFree
Glycosylhydrazines preparation immobilization and reactions of g does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycosylhydrazines preparation immobilization and reactions of g, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosylhydrazines preparation immobilization and reactions of g will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1854627