Glycosylation-mediated inhibition of factor X

Details Glycosylation-mediated inhibition of factor X Glycosylation-mediated inhibition of factor X

1994-09-06

1998-08-25

Lankford, Jr., Leon B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 424 941, 424 945, 530380, 530381, 530384, A61K 3816, A61K 3836, A61K 3843

Patent

active

057983321

ABSTRACT:
Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an .alpha.2-6 linkage are able to inhibit the conversion of human Factor X to human Factor Xa. These reagents (SA/Gal/GalNAc binding reagents) as well as other strategies for inhibiting the conversion of Factor X to Factor Xa are useful in treating thrombosis, inflammation and other conditions associated with excess thrombin activity.

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