Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1995-09-29
2000-02-22
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424450, 4241791, 4241811, 5303919, 5303915, 530350, 530395, 530402, A61K 39395
Patent
active
060277262
ABSTRACT:
The present invention provides glycosylated protein-liposome compositions which are useful for the targeted delivery of a therapeutic agent. The compositions contain an oxidized protein, typically an antibody, which is covalently attached to a lipid by means of a crosslinking agent having an acid hydrazide functionality on one terminus and a sulfhydryl functionality on the other terminus. The lipid is present in a liposome formulation. Methods for preparing the compositions are also provided. In the methods, a glycosylated protein is first oxidized then reacted with a lining group having an acid hydrazide on one end and a sulfhydryl or protected sulfhydryl group on the other end. The resultant modified protein is then reacted with a liposome formulation of a lipid having a sulfhydryl reactive functional group to covalently attach the protein to the liposome.
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Inex Phamaceuticals Corp.
MacMillan Keith D.
Wessendorf T. D.
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