Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-06-21
2005-06-21
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S205100, C424S208100, C530S350000, C530S302000, C530S323000, C435S069100
Reexamination Certificate
active
06908617
ABSTRACT:
A modified polypeptide corresponding to an envelope glycoprotein of a primate lentivirus is described. The polypeptide has been modified from the wild-type structure so that it has at least two of the glycosylation sites proximal to the CD4 binding site or chemokine receptor site altered so that the alteration prevents glycosylation at that site or where glycosylation sites distal to these sites have been derivatized with a molecular adjuvant, while retaining the overall 3-dimensional structure of a discontinuous conserved epitope of the wild-type protein. Preferably, the polypeptide has both changes. Preferably, the primate lentivirus is HIV, and the protein is HIV-1 gp 120.
REFERENCES:
patent: 5817316 (1998-10-01), Thali
patent: 093/17705 (1993-09-01), None
Lekutis et al. Journal of Acquired Immune Deficiency Syndromes 1992, vol. 5, pp. 78-81.
Lee et al. P.N.A.S. USA 1992, vol. 89, pp. 2213-2217.
Bolmstedt et al. J. Gene Virol. 1991, vol. 72, pp. 1269-1277.
Alkhatib, G., et al.,Science272:1955-1958 (1996).
Allan, JS., et al.,Science228:1091-1093 (1985).
Altschul, SF., et al.,Nucleic Acids Res.25:3389-3402 (1997).
Arendrup, et al.,J. AIDS5:303-307 (1992).
Arthos, J., et al.,Cell57:469 (1989).
Baggioline, M., et al.,Adv. Immunol.55:97-179 (1994).
Barre-Sinousi, F., et al.,Science220:868-871 (1983).
Berkower, et al.,J. Exp. Med.170:1681-1695 (1989).
Berman, PW., et al.,Nature345:622-625 (1990).
Binley, J., et al.,AIDS Res. Hum. Retroviruses, 14:191-198 (1997).
Bolmstedt, A., et al.,J. AIDS12:213-220 (1996).
Brodsky, MH., et al.,J Immunol. 144:3078-3086 (1990 ).
Bruck, et al.,Vaccine12:1141-1148 (1994).
Bullough, P., et al.,Nature371:37-43 (1994).
Burton, et al.,Science266:1024-1027 (1994).
Cao, J., et al.,J. Virol.71:9808-9812 (1997).
Carr, CM., et al.,Cell73:823-832 (1993).
Chan, DC., et al.,Cell89:263-273 (1997).
Chen, CH., et al.,J. Virol. 69:3771-3777 (1995).
Chen, Z., et al.,J. Virol.71:2705-2714 (1997).
Cheng-Mayer, C., et al.,Science240:80-82 (1988).
Choe, H., et al.,Cell85:1135-1148 (1996).
Clark, SJ, et al.,N. Engl. J. Med. 324:950-960 (1991).
Cocchi, F., et al.,Nature Med. 2:1244-1247 (1996).
Cocchi, F., et al.,Science270:1811-1815 (1995).
Connor, R., et al.,J. Exp. Med. 185:628 (1997).
Connor, RI., et al.,J. Virol. 67:1772-1778 (1993).
Coombs, RW., et al.,N. Engl. J. Med. 321:1626-1631 (1989).
Cordonnier, A., et al.,Nature340:571-574 (1989).
D'Souza, et al.,J. Infect. Dis. 175: 1056-1062 (1997).
Daar, ES., et al.,N. Engl. J. Med. 324:961-964 (1991).
Daar, et al.,Proc. Natl. Acad. Sci. USA 87:6574-6578 (1990).
Dalgleish, AG., et al.,Nature312:763-767 (1984).
Dalum, et al.,Mol. Immunol. 34:1113-1120 (1997).
Davidson, et al.,Nat. Genet3:219 (1993).
Dean, M., et al.,Science273:1856-1862 (1996).
Dempsey, P., et al.,Science271:348-350 (1996).
Deng, HK., et al.,Nature381:661-666 (1996).
Doranz, BJ., et al.,Cell85:1149-1158 (1996).
Dragic, T., et al.,Nature381:667-673 (1996).
Earl, PL., et al.,J. Virol. 65:2047-2055 (1991).
Earl, PL., et al.,Proc. Natl. Acad. Sci. USA 87:648-652 (1990).
Emini, et al.,Nautre355:728-730 (1991).
Fauci, AS., et al.,Ann. Inter. Med. 124:654-663 (1996).
Feng, Y., et al.,Science272:872-877 (1996).
Fenyo, E., et al.,J. Virol. 62:4414-4419 (1988).
Freed, E., et al.,Proc. Natl. Acad. Sci.USA 87:4650-4654 (1990).
Fung, et al.,J. Virol. 66:848-856 (1992).
Gallo, RC., et al.,Science224:500-503 (1984).
Gegerfelt, et al.,Virology185:162-168 (1991).
Geller, AI., et al.,J. Neurochem64:487 (1995).
Geller, AI., et al.,Proc Natl. Acad. Sci. U.S.A. 87:1149 (1990).
Geller, AI., et al.,Proc Natl. Acad. Sci. U.S.A. 90:7603 (1993).
Gerard, N., et al.,Curr. Opin. Immunol. 6:140-145 (1994).
Girard, et al.,Proc. Natl. Acad. Sci. USA 88:542-546 (1991).
Gorny, et al.,J. Virol. 66:7538-7542 (1992).
Haigwood, et al.,AIDS Res. Hum. Retro. 6:855-869 (1990).
Haigwood, et al.,J. Virol. 66:172-182 (1992).
Ho, DD., et al.,N. Engl. J. Med. 321:1621-1625 (1989).
Ho, et al.,J. Virol. 65:489-493 (1991).
Javaherian, et al.,Science250:1590-1593 (1990).
Kang, et al.,Proc. Natl. Acad. Sci. USA 88:6171-6175 (1991).
Kaplitt, MG., et al.,Nat. Genet. 8:148 (1994).
Karlsson, G., et al.,J. Virol. 71:4218 (1997).
Klaniecki, et al.,AIDS Res. Hum. Retro. 7:791-798 (1991).
Klatzmann, D., et al.,Nature London312:767-68 (1984).
Kowalski, M., et al.,Science237:1351-1355 (1987).
Lasky, L., et al.,Cell50:975-985 (1987).
LeGal LaSalle, et al.,Science259:988 (1993).
Leonard, CK., et al.,J. Biol. Chem. 265:10373-10382 (1990).
Liu, R., et al.,Cell86:367-378 (1996).
Lu, M., et al.,Nature Structural Biol. 2:1075-1082 (1995).
Marcon, L., et al.,J. Virol. 71:2522-2527 (1997).
Matthews, et al.,Proc. Nat. Acad. Sci. USA 83:9707-9713 (1986).
McKeating, et al.,J. Virol. 67:4932-4944 (1993).
McKeating, et al.,Virology190:134-142 (1992).
Moebius, U., et al.,J. Exp. Med. 176:507-517 (1982).
Moore, et al.,J. Virol. 69:101-109 (1995).
Moore, et al.,J. Virol. 67:6136-6151 (1993).
Moore, et al.,J. Virol. 67:863-875 (1993).
Moore, et al.,J. Virol. 69:122-133 (1995).
Moore, et al.,J. Virol. 70:1863-1872 (1996).
Moore, J., et al.,J. Virol. 68:469-484 (1994).
Moore, J., et al.,J. Virol. 68:8350-8364 (1994).
Muster, et al.,J. Virol. 67:6642-6647 (1993).
Myers, G., et al., “Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences,”Los Alamos National Laboratory, (1994).
Nara, et al.,J. Virol. 64:3779-3791 (1990).
Ohno, et al.,Proc. Natl. Acad. Sci. USA 88:10726-10729 (1991).
Olshevsky, U., et al.,J. Virol. 64:5701-5707 (1990).
Peterson, A., et al.,Cell54:65-72 (1988).
Pinter, A., et al.,J. Virol. 63:2674-2679.
Pollard, S., et al.,EMBO J. 11:585-591 (1992).
Posner, et al.,J. Immunol. 16:4325-4332 (1991).
Premack, BA., et al.,Nature Medicine11:1174-1178 (1996).
Profy, et al.,J. Immunol. 144:4641-4647 (1990).
Roben, P., et al.,J. Virol. 68:4821-4828 (1994).
Robey, W., et al.,Proc. Natl. Acad. Sci. USA83:7023-7027 (1986).
Robey, WG., et al.,Science228:593-595 (1985).
Robinson, J., et al.,AIDS Res. Hum. Retro6:567-580 (1990).
Rusche, et al.,Proc. Natl. Acad. Sci. USA 84:6924-6928 (1987).
Rusche, J., et al.,Proc. Natl. Acad. Sci. USA85:3198-3202 (1988).
Ryu, SE., et al.,Nature London348:419-425 (1990).
Samson, M., et al.,Nature382:722-725 (1996).
Sattentau, Q., et al.,J. Exp. Med. 174:407-415 (1991).
Sattentau, Q., et al.,J. Virol. 67:7388-7393 (1993).
Sawyer, et al.,J. Virol. 67:1342-1349 (1994).
Schuitemaker, H., et al.,J. Virol. 66:1354-1360 (1991).
Speck, R., et al.,J. Virol. 71:7136-7139 (1997).
Starcich, BR., et al.,Cell45:637-648 (1986).
Steimer, et al.,Science254:105-108 (1991).
Sullivan, et al.,J. Virol. 69:4413-4422 (1995).
Thali, et al.,J. Virol. 65:6188-6193 (1991).
Thali, et al.,J. Virol. 66:5635-5641 (1992).
Thali, M., et al.,J. Virol. 67:3978-3988 (1993).
Tilley, et al.,Res. Virol. 142:247-259 (1991).
Trkola, A., et al.,J. Virol. 70:1100-1108 (1996).
Trkola, A., et al.,Nature384: 184-187 (1996).
Wang, J., et al.,Nature London348:411-418 (1990).
Watkins, B., et al.,J. Virol. 67:7493 (1993).
Weissenhorn, W., et al.,EMBO J. 15:1507-1514 (1996).
Weissenhorn, W., et al.,Nature387:426-430 (1997).
Wu, L., et al.,Nature384:179-183 (1996).
Wyatt, et al.,J. Virol. 69:5723-5733 (1995).
Wyatt, R., et al.,J. Virol. 67:4557-4565 (1993).
Wyatt, R., et al.,J. Virol. 72:9722-9731 (1997).
Yang, et al.,J. Virol. 69:2004 (1995).
Zhang, L., et al.,Nature383:768 (1996).
Zhu, T., et al.,Science261:1179-1181 (1993).
Hendrickson Wayne A.
Kwong Peter D.
Sodroski Joseph G.
Wyatt Richard T.
Dana-Farber Cancer Institute Inc.
Li Bao Qun
Nixon & Peabody LLP
Salimi Ali R.
The Trustees of Columbia University in the City of New York
LandOfFree
Glycosylated modified primate lentivirus envelope polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycosylated modified primate lentivirus envelope polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosylated modified primate lentivirus envelope polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3518415