Glycosylated insulin derivatives

Details Glycosylated insulin derivatives Glycosylated insulin derivatives

1982-11-17

1984-04-24

Waddell, Frederick E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424178, C07C10352, A61K 3726

Patent

active

044446837

ABSTRACT:
Synthesized succinyl and glutaryl glucosamines, p-(succinylamido)-phenyl-.alpha.-D-gluco- and mannopyranosides, p-(glutarylamido)-phenyl-.alpha.-D-gluco- and mannopyranosides and p-(isothiocyanotophenyl)-.alpha.-D-gluco- and mannopyranosides are reacted with insulin to form corresponding glycosylated insulins containing from 1 to 3 glycosyl groups per insulin molecule. The novel glycosylated insulins resist aggregation and show significant activity in depressing blood sugar levels.

REFERENCES:
patent: 3591574 (1971-07-01), Fenichel et al.

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