Glycosylated ginkgolide derivatives, their application as medici

Details Glycosylated ginkgolide derivatives, their application as medici Glycosylated ginkgolide derivatives, their application as medici

1999-11-30

2000-11-07

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 185, A61K 3170, C07G 300

Patent

active

061437255

DESCRIPTION:

BRIEF SUMMARY
The present invention relates to new glycosylated derivatives of ginkgolides, as well as their use as medicaments. Such derivatives can in particular be used in pharmaceutical compositions.
The properties of ginkgolides (anti-PAF ("Platelet Activating Factor") activity, inhibition of the formation of free radicals, inhibition of the release of glucocorticoids, etc.) are known (cf. in particular Patent Applications DE-A 35 14 054, EP 0 431 535; Amri, Ogwuegbu, Boujrad, Drieu, Papadopoulos, Endocrinology, 137(12), 5707-5718). However, their pharmaceutical activity is limited by their low solubility in water. The Applicant has noted that the glycosylation of these ginkgolides leads to new hydrosoluble products, therefore more easily usable for pharmaceutical compositions whilst preserving the initial biological activity of the ginkgolides or even improving it.
The invention relates in particular to mono-, di-, or, if appropriate tri- or tetraglycosylated derivatives of ginkgolides A, B, C, J or M (structures given in the diagram below; these compounds can be isolated from leaf extracts of Ginkgo biloba--see GINKGOLIDES, Chemistry, Biology, Pharmacology and Clinical Perspectives, edited by P. Braquet, J. R. Prous Science Publishers, in particular Volumes 1 (1988) and 2 (1989)). It also relates to glycosylated derivatives of alkoxylated derivatives of ginkgolides, i.e. those comprising at least one linear or branched alkoxy group, instead of a hydroxy group (these compounds are described in the French Patent Application FR 88.14392).


______________________________________ #STR1## Ginkgolide W X Y Z ______________________________________ A OH OH H H B OH OH OH H C OH OH OH OH J OH OH H OH M H OH OH OH ______________________________________ Structure of ginkgolides A, B C, J and M
The invention relates to a compound of the general formula (I) ##STR2## in which W, X, Y and Z represent independently H, OH, linear or branched alkoxy radicals, or O--G.sub.s, G.sub.s --OH representing a mono- or a disaccharide, or one of their derivatives or analogues, it being understood that at least one of W, X, Y or Z represents an O--G.sub.s radical.
The invention preferably relates to a compound of general formula (I) ##STR3## in which X represents an OH or O--G.sub.s radical, G.sub.s --OH representing a mono- or a disaccharide, or one of their derivatives or analogues, and: represents H; O--G.sub.s radical and Z represents H; O--G.sub.s radical and Z represents an OH or O--G.sub.s radical; represents an OH or O--G.sub.s radical; OH or O--Gs radical; alkoxy radical and Z represents H; O--G.sub.s radical.
The invention relates more particularly to a compound of the general formula (I) ##STR4## in which X represents an OH or O--Gs radical, G.sub.s --OH representing a mono- or a disaccharide, or one of their derivatives or analogues, and: H; and Z represents H; alkoxy radical and Z represents H; it being understood that at least one of W, X, Y or Z represents an O--Gs radical.
By linear or branched alkoxy radical is understood in the present description an alkoxy radical, the carbonated chain of which, linear or branched, has 1 to 6 carbon atoms. By mono- or disaccharide derivative or analogue is meant compounds such as N-acetylglucosamine, the N-acetylalosamine, galactosamine, mannoseamine, N-tosylhydrazone, etc.
Preferably, O--G.sub.s will be chosen such that G.sub.s --OH forms part of the group composed of abequose, rhamnose, arabinose, ribose, xylose, 2-deoxyribose, glucose, galactose, mannose, 2-deoxyglucose, fructose, fucose, N-acetylglucosamine, N-acetylalosamine, galactosamine, mannosamine, saccharose, lactose, maltose, cellobiose and trehalose. In a yet more preferable manner, O--G.sub.s will be chosen such that G.sub.s --OH forms part of the group composed of glucose and lactose.
The invention therefore relates in particular to glycosylated derivatives of ginkgolides, more particularly those of ginkgolides A and B, the glycosyl groups suitable for the invention being described previously.
T

REFERENCES:
patent: 4734280 (1988-03-01), Braquet
patent: 5002965 (1991-03-01), Ramwell et al.
patent: 6030621 (2000-02-01), Long et al.

Affiliated with

Also associated with

Rating

Glycosylated ginkgolide derivatives, their application as medici does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glycosylated ginkgolide derivatives, their application as medici, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosylated ginkgolide derivatives, their application as medici will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1641165