Glycosylated cytokines

Details Glycosylated cytokines Glycosylated cytokines

1995-05-31

1997-07-01

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 424 854, 514 8, 514 12, 514894, 530351, 530395, 530402, 530411, A61K 3870, A61K 3821, C07K 1454, C07K 14555

Patent

active

056435649

ABSTRACT:
Disclosed is a sugar-modified cytokine which ensures migration of almost all of the dose of cytokine to the liver rapidly after administration to the live body and which can be advantageously used to enhance the effect of liver disease therapy and mitigate side effects.

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patent: 4902502 (1990-02-01), Nitecki et al.
patent: 5096816 (1992-03-01), Maiorella
patent: 5162503 (1992-11-01), Bailon et al.
Takenaga et al., "Galactose-conjugated Interferon Alpha", Drug Delivery System, vol. 8(5), p. 382, Sep. 1993.
Yoshito Ohtsubo et al., "Hepatic Targeting of Proteins Utilizing Carbohydrate Recognition Mechanism" Drug Delivery System, vol. 6, No. 1, Jan. 1991 (original Japanese and English translation).
Yuan Chuan Lee et al., "2-Imino-2-methoxyethyl 1-Thiglycosides: New Reagents for Attaching Sugars to Proteins", Biochemistry, vol. 15, No. 18, (1976) pp. 3956-3963.
Lee et al. Biochemistry 21(24): 6292-6298 1982.
Lee et al. "Further Studies on the Binding Characteristics of Rabbit Liver Galactose/N-Acetylgalactosamine-Specific Lectin " Biochemistry 21(24):6292-6298, 1982.

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