Glycosylated analogs of camptothecin

Details Glycosylated analogs of camptothecin Glycosylated analogs of camptothecin

1995-04-27

1997-10-14

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 172, 536 179, 536 181, A61K 3170, C07H 1524

Patent

active

056772866

ABSTRACT:
The present invention relates to chemotherapeutic agents, and more particularly, to novel analogs of camptothecin. The camptothecin analogs display increased solubility through the hydrophilicity of added non-ionic sugar substituents. In accordance with the present invention, a member from the class of novel camptothecin analogs is to be delivered in vivo as a chemotherapeutic agent to fight cancer growth in the body.

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T.A. Houston, Thesis, University of Michigan, (Oct. 15, 1993).

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