Glycosyl sulfotransferase-3

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S004000, C435S006120, C435S069100, C435S183000, C435S192000, C435S252300, C435S320100, C435S325000, C536S023200, C536S023500

Reexamination Certificate

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06967093

ABSTRACT:
A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith.

REFERENCES:
patent: 5185326 (1993-02-01), Muller et al.
patent: 5227369 (1993-07-01), Rosen et al.
patent: 5318890 (1994-06-01), Rosen et al.
patent: 5340934 (1994-08-01), Termine et al.
patent: 5580862 (1996-12-01), Rosen et al.
patent: 5695752 (1997-12-01), Rosen et al.
patent: 6265192 (2001-07-01), Bistrup et al.
patent: 2002/0164748 (2002-11-01), Bistrup et al.
patent: 0 821 066 (1998-01-01), None
patent: 1130094 (2001-09-01), None
patent: WO 92/13102 (1992-08-01), None
patent: WO 00/14251 (2000-03-01), None
patent: WO 00/58473 (2000-10-01), None
patent: WO 01/85177 (2001-11-01), None
Aparicio et al. (PIR Database, Accession NoT30228,) Gene, vol. 169:9-16, 1996.
Lifeseq clone#2617407 Bistrup et al., Mar. 22, 2001.
Lifeseq clone #2620445 Bistrup et al., Mar. 22, 2001.
Bistrup et al., 1999,J. Cell Biol. vol. 145: 899-910.
Baumhueter, Susanne, et al., (1993) “Binding of L-Selectin to the Vascular Sialomucin CD34,”Science, vol. 262:436-438.
Bertozzi, Carolyn, et al., (1995) “Sulfated Dissacharide Inhibitors of L-Selectin: Deriving Structural Leads from a Physiological Selectin Ligand,”Biochemistry, vol. 34(44):14271-14278.
Boukerche, Habib, et al., (1996) “A Monoclonal Antibody Directed Against A Granule Membrane Glycoprotein (GMP-140/PADGEM, P-Selcetin, CD62P) Inhibits Ristocetin-Induced Platelet Aggregation,”British Journal of Haemathology, vol. 92:442-451.
Celi, Alessandro, et al., (1997) “Platelet-Leukocyte-Endothelial Cell Interaction On The Blood Vessel Wall,”Seminars in Hematologyvol. 34(4):327-335.
Crommie, Deidre, et al., (1995) “Biosynthesis of GlyCAM-1, a Mucin-Like Ligand for L-Selectin,”The Journal of Biological Chemistry, vol. 270 (38):22614-22624.
Frenette, Paul S., et al., (1995) “Platelets Roll on Stimulated Endothelium in vivo: An Interaction Mediated By Endothelial P-Selectin,”Proc. Natl. Acad. Sci., vol. 92:7450-7454.
Fukuta, Masakazu, et al., (1995) “Molecular Cloning and Expression of Chick Chondrocyte Chondroitin 6-Sulfotransferase,”The Journal of Biological Chemistry, vol. 270(31):18575-18580.
Fukuta, Masakazu et al., (1997) “Molecular Cloning and Characterization of Human Keratan Sulfate Gal-6-Sulfotransferase,”The Journal of Biological Chemistry, vol. 272 (51):32321-32328.
Girard, Jean-Philippe, et al., (1995) “High Endothelial Venules (HEVs): Specialized Endothelium For Lymphocyte Migration,”Immunology Today, vol. 16(9):449-457.
Habuchi, Hiroko, et al., (1998) “Molecular Characterization and Expression of Heparan-sulfate 6-Sulfotransferase,”The Journal of Biological Chemistry, vol. 273(15):9208-9213.
Habuchi, Osami, et al., (1997) “Sulfation of Sialyl Lactosamine Oligosaccharides By Chrondroitin 6-Sulfotransferase,”Gycobiology, vol. 7 (3):405-412.
Habuchi, Osami, et al., (1996) “Enzymatic Sulfation of Galactose Residue of Keratan Sulfate By Chrondroitin 6-Sulfotransferase,”Glycobiology, vol. 6(1):51-57.
Habuchi, Osami, et al., (1993) “Purification of Chondroitin 6-Sulfotransferase Secreted from Cultured Chick Embryo Chrondrocytes,”The Journal of Biological Chemistry, vol. 268, No. (29):21968-21974.
Hemmerich, Stefan, et al., (1995) “Structure of the O-Glycans in GlyCAM-1, An Endothelial-Derived Ligand for L-Selectin,”The Journal of Biological Chemistry, vol. 270, No. (20):12035-12047.
Hemmerich, Stefan, et al., (1994) “Sulfation-Dependent Recognition of High Endothelial Venules (HEV)-Ligands by L-Selectin and MECA 79, an Adhesion-Blocking Monoclonal Antibody,”The Journal of Experimental Medicine, vol. 180:2219-2226.
Hemmerich, Stefan, et al., (1994) “6′-Sulfated Sialyl Lewis x Is a Major capping Group of GlyCAM-1,”Biochemistry, vol. 33, No. (16):4830-4835.
Hemmerich, Stefan, et al., (1994) “Identification of the Sulfated monosaccharides of GlyCAM-1, an Endothelial-Derived Ligand for L-Selectin,”Biochemistry, vol. 33, No. (16):4820-4829.
Hillier, Marra M., et al., (1996) “The WashU-HHMI Mouse EST Project,”Nucleotide Query, Accession No. AA522184.
Hooper, Lora V., et al., (1996) “From Legumes to Leukocytes:Biological Roles For Sulfated Carbohydrates,”The FASEB Journalvol. 10:1137-1146.
Koenig, Andrea, et al., (1997) “Selectin Inhibition: Synthesis and Evaluation of Novel Sialylated, Sulfated and Fucosylated Oligosaccharides, Including The Major Capping Group of GlyCAM-1,”Glycobiology, vol. 7, No. (1):79-93.
Lasky, Laurence A., et al, (1992) “An Endothelial Ligand for L-Selectin Is a Novel Mucin-Like Molecule,”Cell, vol. 69:927-938.
Marra et al. (Sep. 12, 1996) Genbank EST database accession No. gb_est15:AA522184.
Mitsuoka, Chikako, et al., (1998) “Identification of a major Carbohydrate Capping Group of the L-selectin Ligand on High Endothelial Venules in Human Lymph Nodes as 6-Sulfo Sialyl Lewis X*,”The Journal of Biological Chemistry, vol. 273(18):11225-11233.
Robinson et al. (1995) “Singular over-representation of an octameric palindrome, HIP1, in DNA from many cyanobacteria.”Nucleic Acids Research, vol. 23(5):729-735.
Rosen, Steven D., et al., (1994) “The Selectins and their Ligands,”Current Opinion in Cell Biology, vol. 6:663-673.
Sawada, Mikiko, et al., (1993) “Specific Expression of a Complex Sialyl Lewis X Antigen on High Endothelial Venules of Human Lymph Nodes: Possible Candidate for L-Selectin Ligand,”Biochemical and Biophysical Research Communications, vol. 193, No. (1):337-347.
Spiro, Robert G., et al., (1998) “Characterization of a spleen sulphotransferase responsible for the 6-O-sulphation of the galactose residue in sialyl-N-acetyl-lactosamine sequences,”Biochem J., vol. 331:265-271.
Tsuboi, Shigeru, et al., (1996) “6′-Sulfo Sialyl Lexbut Not 6-Sulfo Sialyl LexExpressed on the Cell Surface Supports L-Selectin-Mediated Adhesion,”The Journal of Biological Chemistry, vol. 271, No. (44):27213-27216.
Yoshino, Kochichiro, et al., (1997) “Studies on Selectin Blockers. 4. Structure-Function Relationship of Sulfated Sialyl Lewis X Hexasaccharide Ceramides toward E-, P-, and L-Selectin Binding,”J. Med. Chem., vol. 40:455-462.

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