Glycosulfopeptide inhibitors of leukocyte rolling and...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

Reexamination Certificate

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C530S324000, C530S325000, C530S326000, C530S327000, C530S322000, C530S333000, C530S344000, C530S402000, C530S412000, C514S042000, C514S008100, C514S023000, C514S025000, C424S009100

Reexamination Certificate

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11239576

ABSTRACT:
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 5047335 (1991-09-01), Paulson et al.
patent: 5180674 (1993-01-01), Roth
patent: 5382657 (1995-01-01), Karisiewicz et al.
patent: 5766897 (1998-06-01), Braxton
patent: 5821329 (1998-10-01), Lobl et al.
patent: 5827817 (1998-10-01), Larsen et al.
patent: 5858994 (1999-01-01), Kretzschmar et al.
patent: 5874261 (1999-02-01), Roth
patent: 5929036 (1999-07-01), McEver
patent: 5972885 (1999-10-01), Spira et al.
patent: 6136790 (2000-10-01), Toepfer et al.
patent: 6165509 (2000-12-01), Hoffman et al.
patent: 6177087 (2001-01-01), Greenwald et al.
patent: 6250469 (2001-06-01), Kline
patent: 6593459 (2003-07-01), Cummings et al.
patent: 2002/0026033 (2002-02-01), Cummings et al.
patent: 2003/0130174 (2003-07-01), Cummings et al.
patent: 2003/0144183 (2003-07-01), Cummings et al.
patent: 0577580 (1994-01-01), None
patent: 9411498 (1994-05-01), None
patent: 9706176 (1997-02-01), None
patent: PCT/US99/13455 (1999-06-01), None
patent: WO99/65712 (1999-12-01), None
patent: PCT/US02/33535 (2003-11-01), None
Amado et Ali., “A Family of Human 3-galactosyltransferases,” J. Biol. Chem., (May 22, 1998) 273 (21): 12770-12778.
Bierhuizen et al., “Expression Cloning of a cDNA encoding UDP-GlcNAc:Galβ1-3-GalNAc-R (GlcNAc to GalNAc) β1-6GlcNAc transferase by Gene Transfer Into CHO Cells Expressing Polyoma Large Tumor Antigen,” Proc. Natl. Acad. Sci. USA, 89:9326-9330, Oct. 1992.
Brockhausen et al., “Control of 0-glycan synthesis: specificty and inhibition of 0-glycan core 1 UDP-galactose: N-acetylgalactosamine- -R3-galactosyltransferase from rat liver,” Biochem, Cell Biol., (1992) 70: 99-108.
Brockhausen et al., “Enzymatic basis for sialyl-Tn expression in human colon cancer cells,” Glycoconjugate Journal, (1998) 15:595-603.
Cheng et al., “Mucin Biosynthesis,” J. Biol. Chem., (1982) 257 (11): 6251-6258.
Delhom et al., “Synthesis of Sulfated Bioactive Peptides Using Immobilized Arylsufotransferase from Eubacterium,” sp.Biotechnol. Lett.May 1996, vol. 18, No. 5, pp. 609-614, entire document.
Granovsky et al., “UDPgalactose: glycoprotein-N-acetyl-D-galactosamine 3-3-D-galactosyltransferase activity synthesizing O-glycan core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates,” Euro. J. Biochem., (1994) 22:1039-1046.
Harris et al., “Pegylation A Novel Process for Modifying Pharmacokinetics,” Clin Pharmacokinet 2001; 40(7); 539-551.
Hicks, et al., “Glycosulfopeptides modeled on P-selectin glycoprotein ligand 1 inhibit P-selectin-dependent leukocyte rolling in vivo”, FASEB Journal, Sep. 2002, vol. 16, No. 11, pp. 1461-1462, especially p. 1462.
Hicks, et al., Glycosulfopeptides Modeled on PSGL-1 Inhibit P-selectin-dependent Leucocyte Rolling in Vivo. FASEB Journal, Mar. 2002, vol. 15, No. 5, p. A1052, see abstract.
Leppanen et al., “Binding of Glycosulopeptides to P-selectin Requires Stereospecific Contributions of Individual Tyrosine Sulfate and Sugar Residues” J. Biol. Chem., (2000) 275 (50): 39569-39578.
Leppanen et al., “A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin” J. Biol. Chem., (1999) 274 (35): 24838-24848.
Lo-Guidice et al., “Sialylationa nd Sulfation of the Carbohydrate Chains in Respiratory Mucins from a Patient with Cystic Fibrosis,” J. Biol. Chem., (Jul. 1994) 269 (29): 18794-18813.
Lopez et al., “O-Glycosylation potential of lepidopteran insect cell lines,” Biochimica et Biophysica Acta (1999) 1427:49-61.
Meier et al., “The ELAM LIgand Fucosyltransferase, ELFT, Directs E-Selectin Binding to a Secreted Scaffold Protein: A Method to Produce and Purify Large Quantities of Specific Carbohydrate Structures,”Chemical Abstracts, XP-002124245, 119(17), 20/25/93.
Moore et al., “The P-Selectin Glycoprotein Ligand From Human Neutrophils Displays Slalylated, Fucosylated, O-Linked Poly-N-Acetyllactosamine,”The Journal of Biological Chemistry, 269(37):23318-23327, 1994.
Nishimune et al., “Detection of protein-protein interactionns in the nervous system using the two-hybrid system,” Trends Neurosci. (1996) 19, 261-266.
Pouyani et al., “PSGL-1 Recvognition of P-Selectin is Controlled by a Tyrosine Sulfation Consensus at the PSGL-1 Amino Terminus,”Cell.Oct. 20, 1995, vol. 83, No. 2, pp. 333-343, entire document.
Sako et al., “A sulfated Peptide Segment at the Amino Terminus of PSGL-1 is Critical for P-Selectin Binding,”Cell.Oct. 20, 1995, vol. 83, No. 2, pp. 323-331, entire document.
Seitz et al., “Chemoenzymatic Solution- and Solid-Phase Synthesos of O-Glycopeptides of the Mucin Domain of MAdCAM-1, A General Route to O-LacNAc, O-Sialyl-LacNAc and O-Sialyl-Lewis-X Peptides,”J. Am. Chem. Soc., 119:8766-8776, 1997.
Sueyoshi et al., “Expression of Distinct Fucosylated Ollgosaccharides and Carbohydrate-Mediated Adhesion Efficiency Directed by Two Different α-1,3-fucosyltransferases,”The Journal of Biological Chemistry, 269(51):32342-32350, 1994.
Thurnher et al., “T cell clones with normal or defective O-galactosylation from a patient with permanent mixed-field polyagglutinability,” Eur. J. Immunol., (1992) 22: 1835-1842.
Wilkins et al., Structures of the O-Glycans on P-Seletin Glycoprotein Ligand-1 from HL-60 Cells.Journal Biol. Chem.Aug. 2, 1996, vol. 271, No. 31, pp. 18732-18742, entire document.
Wilkins et al., “Tyrosine Sulfation of P-selectin Glycoprotein Ligand-1 Is Required for High Affinity Bnding to P-selectin,” J. BIol. Chem., (1995), vol. 270, No. 39, pp. 22677-22680.
Wünsch et al., “Synthesis of Cholecystokinin-Related Peptides and Their Biological Properties,”Biol. Chem. Hoppe-Seylor.Apr. 1989, vol. 370, pp. 317-321, entire document.
Yamamoto et al., “Chemoenzymatic Synthesis of a Novel Glycopeptide Using a Microbial Endoglycosidase,”Caro. Res.Jan. 9, 1998, vol. 305, No. 3-4, pp. 415-422, entire document.

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