Glycosphingolipids with a group capable of coupling in the sphin

Details Glycosphingolipids with a group capable of coupling in the sphin Glycosphingolipids with a group capable of coupling in the sphin

1995-06-02

1996-11-05

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 187, 536 551, 4241847, C07G 300, C07H 504, A61K 3900

Patent

active

055719007

ABSTRACT:
The invention relates to the chemical modification of the sphingoid portions of glycosphingolipids. It has been possible by a series of reactions to introduce an amino group in the position of the carbon double-bond in the sphingoid portion after elimination of the long-chain aldehyde. Glycosphingolipids of the formula (2) and (3), where X and Y denote a group capable of coupling, are suitable for coupling to other molecules, preferably proteins. X preferably represents NH.sub.2, and Y preferably represents ##STR1##

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