Glycoside-hydrolase enzyme inhibitors

Details Glycoside-hydrolase enzyme inhibitors Glycoside-hydrolase enzyme inhibitors

1974-07-31

1977-03-22

Monacell, A. Louis

Textiles: fiber preparation

195 80R, 424181, 426321, C12B 1300

Patent

active

040135101

ABSTRACT:
This invention relates to inhibitors for glycosidehydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (arteriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycoside-hydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, adipose, hyperlipidemia (arteriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.

REFERENCES:
patent: 3127315 (1964-03-01), Tardrew et al.
patent: 3629404 (1971-12-01), Florent et al.
Niwa et al., "Nojirimycin," as a Potent Inhibitor of Glucosidase," Agr. Biol. Chem., Vol. 34, No. 6, pp. 966-968, (1970).

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