Glycoside-ether-ester compounds

Details Glycoside-ether-ester compounds Glycoside-ether-ester compounds

1976-06-21

1979-01-30

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424 11, 424 85, 536 4, 536 53, 536115, 536119, C07H 1306

Patent

active

041374010

ABSTRACT:
Carbohydrate antigenic determinants containing a glycosidically linked bridging arm are synthesized and coupled to carrier molecules to form artificial antigens, and to solid supports to form immunoabsorbants. These artificial antigens are used to detect antibodies to the carbohydrate haptens, and to raise antisera specific for the carbohydrate antigenic determinants. The immunoabsorbants are used to purify or remove antibodies to the carbohydrate haptens. Specific examples are given to the synthesis of the Lewis-a, Lewis-b, B, and H(O) blood group antigens; to the preparation of antisera to these artificial antigens, and to the preparation of immunoabsorbants specific for antibodies to these antigens.

REFERENCES:
patent: 2218569 (1940-10-01), White
patent: 3356674 (1967-12-01), Ikeda et al.
patent: 3655645 (1972-04-01), Jacques
patent: 3729461 (1973-04-01), Pomeranz et al.
patent: 3974138 (1976-08-01), Lew
Pigman, "The Carbohydrates", 1957, Academic Press Inc., New York, N. Y., pp. 483-485.

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