Glycosidase inhibitors and use thereof

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Details

548556, C07D20712, A61K 3140

Patent

active

048943886

ABSTRACT:
The specificity of glycosidase inhibitory activity of the novel 1,4-dideoxy-1,4-imino-L-allitol is substantially changed by substituting the ring nitrogen with an alkyl or benzyl substituent.

REFERENCES:
patent: 3312716 (1967-04-01), Biel et al.
Molyneax et al., Arch. Biochem. Biophys. 251, 450-457 (1986).
Elbein, Biochemistry 26, 2502-2510 (1987).
Schweden et al., Eur. J. Biochem. 157, 563-570 (1986).
Hettkamp et al., Eur. J. Biochem. 142, 85-90 (1984).
Fleet and Son, Tetrahedron 44, 2637-2647 (1988).

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